ArticleQuantitative imaging in medicine and surgery2025
Test-retest precision of brain metabolites in healthy participants using
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Metabolite-Specific Reproducibility of CerebralNMR in biomedicine · 2026Article
- Quantitative susceptibility mapping and MRS-based multimodal machine learning for early Parkinson's disease classification.NPJ Parkinson's disease · 2026Article
- Association of decreased thalamic neurotransmitter level with sensorimotor tract damage in patients with relapsing-remitting multiple sclerosis.Quantitative imaging in medicine and surgery · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: Magnetic resonance spectroscopy (MRS) enables the non-invasive quantification of brain metabolites, and its reliability is crucial for accurate interpretation of disease state. This study assessed the test-retest precision of phosphorus-31 ( Methods: In total, 32 participants, who underwent two scanning sessions within three days, using two dimensional (2D)-chemical shift imaging (CSI)- Results: The results revealed that potential of hydrogen (pH) and phosphocreatine (PCr) showed the greatest stability as evidenced by low CVs, suggesting reliable measurements across sessions. The adenosine triphosphates (ATPs) showed considerable stability. Conversely, metabolites, such as phosphomonoesters (PMEs) and phosphodiesters (PDEs), located to the left of PCr, showed reduced stability, while glycerophosphatidylcholine (GPTC) had the highest CV, indicating significant variability in clinical practice. Among the various brain regions, intermediate areas such as the temporal lobe and thalamus exhibited greater stability than peripheral regions such as the frontal and occipital lobes. Single-voxel MEGA-PRESS measurements showed that Glx and GABA+ had higher precision than GSH. Conclusions: Both the
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