Evidence map›Paper›PMID 40235652›Full record

ArticleBioactive materials2025

Semi-synthetic fibrous fibrin composites promote 3D microvascular assembly, survival, and host integration of endothelial cells without mesenchymal cell support.

Firaol S Midekssa, Christopher D Davidson, Megan E Wieger, Jordan L Kamen, Kaylin M Hanna, Danica Kristen P Jayco, Michael M Hu, Nicole E Friend, Andrew J Putnam, Adam S Helms and 2 more

Abstract read
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Firaol S MidekssaDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Christopher D DavidsonDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Megan E WiegerDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Jordan L KamenDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Kaylin M HannaDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Danica Kristen P JaycoDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Michael M HuDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Nicole E FriendDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Andrew J PutnamDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Adam S HelmsDivision of Cardiovascular Medicine, University of Michigan Ann Arbor, MI 48109, United States.
Ariella ShikanovDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan Ann Arbor, MI, 48109, United States.

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Regulation and Enhancement of Angiogenesis in Dense Fibrin MatricesR01HL085339 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTNAM, ANDREW J · 2007 to 2024
$5.4M
Angiogenic hydrogel composites for microvascular integration of organoid graftsR01EB030474 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKER, BRENDON M · 2021 to 2024
$1.4M
Granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance bone tissue regenerationF32AR084876 · NIAMS · UNIVERSITY OF COLORADO · PI Nicole Erin Friend · 2024 to 2026
$228k
NHLBI NIH HHS R01 HL085339NIAMS NIH HHS F32 AR084876NIBIB NIH HHS R01 EB030474NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

Vasculogenic assembly of 3D capillary networks remains a promising approach to vascularizing tissue-engineered grafts, a significant outstanding challenge in tissue engineering and regenerative medicine. Current approaches for vasculogenic assembly rely on the inclusion of supporting mesenchymal cells alongside endothelial cells, co-encapsulated within vasculo-conducive materials such as low-density fibrin hydrogels. Here, we established a material-based approach to circumvent the need for supporting mesenchymal cells and report that the inclusion of synthetic matrix fibers in dense (>3 mg mL

Indexed as

Cell-ECM interactionsEndothelial cellsGraft-host integrationHydrogelsMicrovasculatureVasculogenic assembly

Identifiers

PMID40235652
PMCPMC11999628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.