Evidence map›Paper›PMID 40235645›Full record

ArticleBone reports2025

Intake of eggshell membrane enhances bone mass and suppresses bone marrow adiposity in normal growing rats.

Nao Yashima, Kaoru Fujikawa, Wataru Minamizono, Hiroya Matsunaga, Jiazheng Lyu, Hirai Suito, Takumi Okunuki, Shingo Nakai, Masafumi Ohsako

Abstract read
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In one paragraph

Article in Bone reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nao YashimaGraduate School of Health and Sports Science, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo 115-8650, Japan.
Kaoru FujikawaDepartment of Oral Anatomy, Showa Medical University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-0064, Japan.
Wataru MinamizonoGraduate School of Human Life Design, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo 115-8650, Japan.
Hiroya MatsunagaGraduate School of Health and Sports Science, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo 115-8650, Japan.
Jiazheng LyuGraduate School of Health and Sports Science, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo 115-8650, Japan.
Hirai SuitoDepartment of Anatomy, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
Takumi OkunukiResearch Organization of Science and Technology, Ritsumeikan University/Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
Shingo NakaiDepartment of Judo Seifuku and Health Sciences, Tokoha University Faculty of Health Promotional Sciences, 1230 Miyakoda-cho, Hamana-ku, Hamamatsu-shi, Shizuoka 431-2102, Japan.
Masafumi OhsakoDepartment of Health and Sports Science, Toyo University School of Health and Sports Science, 1-7-11 Akabanedai, Kita-ku, Tokyo 115-8650, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eggshell membrane intake is considered to have beneficial effects on bone health; however, relevant evidence remains scant. Therefore, we aimed to explore the direct effects of eggshell membrane intake on osteogenic function in normal growing rats. Six-week-old male Wistar rats were divided into control (CO) and eggshell membrane (EM) groups. The experiment was conducted over 8 weeks. Visual observation and micro-computed tomography analysis revealed a significant increase in bone mass in the EM group compared with that in the CO group. Histological analysis showed thick and long trabeculae in the EM group, accompanied by an increase in the number of osteoblasts and suppression of adipocyte accumulation. Furthermore,

Indexed as

AdipocyteBone marrow adiposityBone massEggshell membraneOsteoblastRat

Identifiers

PMID40235645
PMCPMC11999470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.