ArticleJournal of exercise science and fitness2025
Mediation role of telomere length in the relationship between physical activity and PhenoAge: A population-based study.
Article in Journal of exercise science and fitness, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Polymorphisms of long non-coding RNA HOTAIR and susceptibility to gastrointestinal cancers: A meta-analysis.Medicine · 2026Pooled it
- Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study.Journal of advanced research · 2026Article
- Cellular senescence and aging: molecular mechanisms and convergent pathways.Cellular and molecular life sciences : CMLS · 2026Review
- The Mediating Effect of Physical Fitness on the Relationship Between Developmental Coordination Disorder and Physical Activity in School-Aged Children-An Observational Study.Life (Basel, Switzerland) · 2026Article
- Article
- Oral microbiome diversity shapes the association between leisure-time physical activity and cognitive function among older adults.iScience · 2026Article
- Establishment and Validation of Machine Learning Model for Predicting Suicide Risk in Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2026Article
- Nonlinear Association of Daily Sitting Time With Depression Risk in US Adults: A Cross-Sectional Study.Behavioural neurology · 2026Article
- Relationships between physical activity dimensions and frailty incidence and progression in middle-aged and older adults: A 7-year cohort study.Journal of exercise science and fitness · 2026Article
- Binational comparison of the association between socioeconomic status and metabolic syndrome: A nationally representative study in South Korea and the United States.Preventive medicine reports · 2025Article
- Association Between the Serum Creatinine to Cystatin C Ratio, Physical Activity, and Frailty in Middle-Aged and Older Adults in China: A Nationwide Cohort Study.Life (Basel, Switzerland) · 2025Article
- Effects of exercise training on systemic arterial pulse wave velocity in postmenopausal women: an updated systematic review and meta-analysis of randomized controlled trials.BMC sports science, medicine & rehabilitation · 2025Article
- Correlates of annual health check-up among community-dwelling persons 60 years and older: Longitudinal national evidence from the health, aging, and retirement in Thailand study, 2015-2022.Preventive medicine reports · 2025Article
- The proportion of moderate-to-vigorous-intensity physical activity to total volume of physical activity correlates with decreased risk of possible sarcopenia: A prospective cohort study.Journal of exercise science and fitness · 2025Article
- The mechanism of how adolescents' physical self-esteem and psychological resilience influence sports participation: the chain mediating roles of exercise motivation and social support.BMC sports science, medicine & rehabilitation · 2025Article
- Exploring the mediating role of telomere length in the association between physical activity and bone mineral density.Aging clinical and experimental research · 2025Article
- Unsupervised clustering of biochemical markers reveals health profiles associated with function and survival in active aging.Scientific reports · 2025Article
- Herbal medicine evaluation for reimbursement-based facial palsy (HERB-FP): a retrospective analysis using Korean health insurance claim data 2020-2024.BMC complementary medicine and therapies · 2025Article
- Knowledge, attitudes, and practices (KAP) regarding nutrition among bodybuilders of Zanjan, Northwest of Iran: a cross-sectional study.BMC sports science, medicine & rehabilitation · 2025Article
- Anxiety, Coping, and Self-Efficacy as a Psychological Adjustment in Mothers Who Have Experienced a Preterm Birth.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research. Methods: The study encompassed a cohort of 6200 participants aged 20 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES). Physical activity (PA) levels were assessed employing the Global Physical Activity Questionnaire, while DNA samples were collected to determine telomere length, measured in base pairs. PhenoAge, an emerging aging index relying on nine distinct chemical biomarkers, was computed. Results: Incorporating a fully adjusted model, our analysis showed significant correlations between PA engagement and PhenoAge [Low PA, β (95 % CI): 0.039(-0.071,-0.008), p = 0.021; Moderate PA, β (95 % CI): 0.058(-0.082,-0.034), p < 0.001; High PA, β (95 % CI): 0.069(-0.096,-0.042), p < 0.001]. Furthermore, a positive link emerged between elevated PA levels and telomere length, with a β (95 % CI) of 0.011(0.001, 0.022), p = 0.034. A mediation analysis was performed, demonstrating that telomere length mediated the connection between PA and PhenoAge, with a proportion mediated calculated at 3.57 %. Conclusions: Our findings suggest that PA may play a key role in mitigating aging processes by preserving telomere length, highlighting the potential of PA as a target for interventions aimed at promoting healthy aging and longevity.
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