ArticleJoint diseases and related surgery2025
Experimental evaluation of nerve graft orientation in a rat model: Functional and histological insights.
Article in Joint diseases and related surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Autograft Polarity on Functional Outcomes Following Experimental Peripheral Nerve Repair Surgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
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7 authors.
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Abstract
objectivesThis study aims to investigate the effect of nerve graft orientation on nerve regeneration in a rat sciatic nerve defect model and to compare functional and histological outcomes of normal and reverse orientation grafts, focusing on sensory and motor recovery. MATERIALS AND
methodsA total of 30 Wistar Albino rats were divided into three equal groups: a control group, a normal graft orientation group (Group A), and a reverse graft orientation group (Group B). A 10-mm sciatic nerve defect was created in the surgical groups, and the graft was applied with epineural coaptation. Functional recovery was evaluated using extensor postural thrust (EPT), pinprick, and hot plate tests, while histological analysis involved axon counts, myelin sheath thickness measurements, and the axon count change ratio.
resultsNo significant difference was observed between Group A and Group B in motor function recovery as evaluated by the EPT test (p>0.05). However, Group A showed improved sensory recovery compared to Group B in the pinprick test (p=0.028). Histologically, both groups demonstrated similar ratios of axon count and myelin sheath thickness between proximal and distal segments (p>0.05).
conclusionNormal autograft orientation demonstrated superior sensory recovery, while no significant differences were observed in motor function or histological results. These findings highlight the importance of graft orientation for sensory regeneration and underscore the need for future studies to explore the long-term effects of graft orientation and its implications for human nerve repair, particularly in larger defects and clinical scenarios.
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