ArticleJoint diseases and related surgery2025
Irisin and its role in fracture healing: A comparative study with hyaluronic acid and platelet-rich plasma in a rat model.
Article in Joint diseases and related surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review).International journal of molecular medicine · 2026Review
- Sex specific effects of irisin on the skeleton.Bone research · 2026Review
- Fracture healing potential of tetracalcium phosphate: An experimental study in a rat femur standardized diaphyseal osteotomy with open approach.Joint diseases and related surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to investigate the effects of local irisin (IR) injections on closed femoral fractures in rats and to compare its efficacy to platelet-rich plasma (PRP) and hyaluronic acid (HA). MATERIALS AND
methodsA total of 64 male Wistar albino rats were divided into four equal groups: a control group that received no treatment and three experimental groups that received local injections of HA, PRP, or recombinant IR at the fracture site. All rats underwent a standard bilateral closed femoral shaft fracture and intramedullary fixation. Each group was further divided into two subgroups, sacrificed at Week 2 and Week 4. The right femurs were used for radiological examination with micro-computed tomography (micro-CT) and subsequent histological analysis, while the left femurs were reserved for biomechanical testing.
resultsBy Week 2, the IR and PRP groups showed statistically significantly higher scores for the transformation of fibrous cartilage into bone tissue compared to the control group (7.88±0.6, p=0.0001, and 6±0.8, p=0.036, respectively). By Week 4, transformation scores in the IR group increased to 9.25±0.7, statistically significantly exceeding the control group (p=0.0001). Bone volume was also statistically significantly greater in the IR group (5.21±0.5 mm
conclusionThe present study is one of the first to demonstrate the potential of administering local IR via injection into the fracture hematoma to accelerate fracture healing. The superior efficacy of IR over HA and PRP may be explained by its ability to enhance osteoblast activity, promote vascularization, and reduce inflammation, creating an optimal environment for bone regeneration. Unlike PRP, which primarily delivers growth factors, and HA, which supports cell migration and proliferation, IR appears to directly influence the bone microenvironment, expediting callus transformation. These findings suggest that IR may play a significant role in improving outcomes for patients at risk of delayed union. However, further clinical trials in humans are necessary to confirm its efficacy and safety for clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.