ReviewJPEN. Journal of parenteral and enteral nutrition2025
Evidence and unknowns for the relevancy of applying current parenteral nutrition support recommendations among infants born less than 750 g or younger than 25 weeks' gestation: A narrative review.
Review in JPEN. Journal of parenteral and enteral nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nutritional management at 22-23 weeks gestational age: evidence and knowledge gaps.Pediatric research · 2026Review
- Evidence and unknowns for the relevancy of applying current parenteral nutrition support recommendations among infants born less than 750 g or younger than 25 weeks' gestation: A narrative review.JPEN. Journal of parenteral and enteral nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With advancements in neonatal care, the viability of extremely low-birth-weight (ELBW) infants, especially those born extremely preterm, is increasing. However, specific recommendations for managing parenteral nutrition (PN) support in nanopreterm infants (<750 g or <25 weeks' gestation) are lacking. We aim to evaluate current recommendations and highlight considerations for applying them to nanopreterm infants. The author team used English-language articles related to nutrition in ELBW with emphasis on nanopreterm infants, along with studies on fetal growth and metabolism. Current PN support recommendations for ELBW infants may not suit nanopreterm infants due to physiological and developmental differences. Key considerations for nanopreterm infants include: Carbohydrate: They require immediate dextrose provision with low glucose infusion rates because of limited glycogen stores, immature gluconeogenesis, and impaired glucose intolerance. Lipids: Although essential for energy storage and cell membrane integrity, the ability to metabolize them may be limited, requiring careful consideration of lipid injectable emulsion provision and dosing. Protein: Protein is crucial for growth and development. However, achieving euglycemia is essential for proper amino acid utilization, requiring a delicate balance of dextrose and protein provision. Energy: Because of lower muscle and tissue mass and immature metabolic capabilities, existing recommendations may overestimate their energy needs. Micronutrients: Exact micronutrient requirements are unknown during this specific period of fetal development. This review highlights the limitations of available PN support recommendations for nanopreterm infants. Further research is needed to establish precise guidelines that optimally meet their nutrition needs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.