Evidence map›Paper›PMID 40235215›Full record

ArticleACS applied materials & interfaces2025

Effect of Tyrosine-Containing Self-Assembling β-Sheet Peptides on Macrophage Polarization and Inflammatory Response.

Jacek K Wychowaniec, Ezgi Irem Bektas, Marcia Muerner, Jiranuwat Sapudom, Martin Šrejber, Marielle Airoldi, Roland Schmidt, Andrea J Vernengo, Charlotte J C Edwards-Gayle, Paul Sean Tipay and 4 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jacek K WychowaniecAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.ORCID 0000-0002-6597-5242
Ezgi Irem BektasAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.
Marcia MuernerAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.
Jiranuwat SapudomLaboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.ORCID 0000-0001-6627-7713
Martin ŠrejberRegional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, 779 00 Olomouc, Czech Republic.ORCID 0000-0001-9556-2978
Marielle AiroldiAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.
Roland SchmidtHitachi High-Tech Europe GmbH, Europark Fichtenhain A12, 47807 Krefeld, Germany.
Andrea J VernengoAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.ORCID 0000-0002-5143-7435
Charlotte J C Edwards-GayleDiamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX110DE, United Kingdom.
Paul Sean TipayLaboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.
Michal OtyepkaRegional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, 779 00 Olomouc, Czech Republic.ORCID 0000-0002-1066-5677
Jeremy TeoLaboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.ORCID 0000-0001-6869-3833
David EglinMines Saint-Étienne, Univ Jean Monnet, INSERM, UMR 1059 Sainbiose, 1059, Saint-Étienne, France.
Matteo D'EsteAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.ORCID 0000-0002-0424-8172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling peptides (SAPs) are fully defined nanobiomaterials offering unprecedented opportunities to control nanostructure and chemical attributes to investigate and manipulate cellular signals. To investigate the influence of chemical and morphological characteristics on inflammatory signaling in native immunity, we designed five β-sheet SAPs: EFEFKFEFK (

Indexed as

InflammationMacrophagesPeptidesTyrosineHumansNanofibersProtein Conformation, beta-StrandTHP-1 CellsPeptidesTyrosineimmunomodulationinflammationmacrophage polarizationnanostructured peptidestyrosine-modified self-assembling peptides

Identifiers

PMID40235215
PMCPMC12086772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.