Evidence map›Paper›PMID 40235202›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Functional roles of interstitial cells of Cajal in the GI tract of rats.

Sung Jin Hwang, Joong Goo Kwon, Elizabeth A H Beckett, Minkyung Kim, Tom Herbert, Kenton M Sanders, Sean M Ward

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Disruption of gastrointestinal PDGFRαAmerican journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sung Jin HwangDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.ORCID 0000-0002-7571-7650
Joong Goo KwonDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.ORCID 0000-0003-3392-785X
Elizabeth A H BeckettDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.ORCID 0000-0001-8256-0375
Minkyung KimDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.
Tom HerbertDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.
Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.ORCID 0000-0002-4196-1583
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, United States.ORCID 0000-0003-0217-1535

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Yumei Feng Earley · 2019 to 2026
$20.3M
Mechanisms underlying regional differences in gastric compliance in the stomach.R01DK057236 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KENTON M SANDERS, Sean M Ward · 2000 to 2026
$7.1M
HHS | National Institutes of Health (NIH) NIH DK057236HHS | National Institutes of Health (NIH) P20GM130459HHS | NIH | National Center for Research Resources (NCRR) 1 S10 RR16871NIDDK NIH HHS R01 DK057236NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

Interstitial cells of Cajal (ICC) are distributed through the gastrointestinal (GI) tract, but the functional role of these cells comes primarily from studies of mice. Whether the functions of ICC are similar in larger animals is largely speculative. We investigated whether the

Indexed as

Gastrointestinal TractInterstitial Cells of CajalAnimalsColonElectrophysiological PhenomenaGastric FundusIntestine, SmallLoss of Function MutationMotor NeuronsProto-Oncogene Proteins c-kitPyloric AntrumRatsProto-Oncogene Proteins c-kitenteric motor neurotransmissionICCpacemaker activityslow waves

Identifiers

PMID40235202
PMCPMC12747247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.