Electrochemical Catheter Hub Operated by a Wearable Micropotentiostat Prevents Acinetobacter baumannii Infection In Vitro.

Majid Al-Qurahi, Derek Fleming, Won-Jun Kim, Ibrahim Bozyel, Robin Patel, Haluk Beyenal

Abstract read

In one paragraph

Article in Biotechnology and bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Majid Al-QurahiThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, USA.ORCID http://orcid.org/0009-0008-5575-9387

Derek FlemingDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0002-0054-904X

Won-Jun KimThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, USA.ORCID http://orcid.org/0000-0003-3948-7672

Ibrahim BozyelDepartment of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.ORCID http://orcid.org/0000-0002-2841-7890

Robin PatelDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0001-6344-4141

Haluk BeyenalThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, USA.ORCID http://orcid.org/0000-0003-3931-0244

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026

$5.5M

National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R01AI091594.NIAID NIH HHS R01 AI091594

6 · The paper itself

Abstract

Intraluminal infection of central venous catheters, used for long-term treatment, can result in central line-associated bloodstream infection (CLABSI). These infections can be challenging to prevent and treat due to formation of biofilms within catheter lumens, which shield bacteria from the human immune response and conventional antimicrobial therapies. Preventing bacterial colonization of catheter hubs is a strategy to prevent CLABSI. To address this, we developed a nonantibiotic, animal-ready electrochemical catheter hub (e-catheter hub), operated by a wearable, battery-powered micropotentiostat (MP), that internally generates tunable hypochlorous acid (HOCl) for preventing intraluminal infection. The design evaluated three different electrode materials-titanium, platinum, and gold-for HOCl generation and biocidal activity, using working and counter electrodes of the same materials and a silver/silver chloride-plated wire as a quasi-reference electrode. e-catheter hubs operated by MPs at 1.5 V

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsCatheter-Related InfectionsElectrochemical TechniquesWearable Electronic DevicesHumansHypochlorous AcidHypochlorous Acidcentral line‐associated bloodstream infectioncentral venous catheterelectrochemical catheter hubhypochlorous acidinfection preventionwearable micropotentiostat

Identifiers

PMID40235195

DOI10.1002/bit.28990

PMCPMC12152523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.