Evidence map›Paper›PMID 40235083›Full record

ArticleThe Journal of small animal practice2025

The effect of lyophilised oral faecal microbial transplantation on functional outcomes in dogs with diabetes mellitus.

R Brown, P Barko, J D J Ruiz Romero, D A Williams, A Gochenauer, J Nguyen-Edquilang, J S Suchodolski, R Pilla, H Ganz, N Lopez-Villalobos and 1 more

Abstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of small animal practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

R BrownDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
P BarkoDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
J D J Ruiz RomeroDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
D A WilliamsDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
A GochenauerDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
J Nguyen-EdquilangDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
J S SuchodolskiGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.
R PillaGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.
H GanzAnimalBiome, Oakland, California, USA.
N Lopez-VillalobosSchool of Agriculture and Environment, Massey University, Palmerston North, New Zealand.
A GalDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Funding

University of Illinois at Urbana-Champaign Companion Animal Research Grant Program
6 · The paper itself

Abstract

objectivesWe aimed to determine if oral faecal microbiota transplantation improves indices of glycaemic control, changes the faecal dysbiosis indices, alters faecal short-chain fatty acid and bile acid profiles and increases serum glucagon-like-peptide 1 concentrations in diabetic dogs. MATERIALS AND

methodsIn this prospective randomised, placebo-controlled, double-blinded pilot study, we recruited nine diabetic dogs (five faecal microbiota transplantation and four placebo) and nine healthy controls.

resultsCompared to healthy dogs, diabetic dogs had altered faecal short-chain fatty acid and bile acid profiles. In the first 30 days, the faecal microbiota transplantation group had a more rapid decline in interstitial glucose; however, the mean interstitial glucose of the faecal microbiota transplantation recipients did not differ from the placebo recipients at the end of the study. Compared with placebo, faecal microbiota transplantation recipients had a decreased 24-hour water intake at day 60 and increased faecal abundance of Faecalibacterium. CLINICAL SIGNIFICANCE: This study provides a proof of concept for faecal microbiota transplantation in canine diabetes, and its data could inform the design of future large-scale studies. Further investigation is required to determine whether faecal microbiota transplantation would have any role as an adjunctive therapy in canine diabetes and to elucidate the mechanisms by which faecal microbiota transplantation may provide a beneficial clinical effect in canine diabetes.

Indexed as

Diabetes MellitusDog DiseasesFecal Microbiota TransplantationAnimalsBile Acids and SaltsBlood GlucoseDogsDouble-Blind MethodFatty Acids, VolatileFecesFemaleGlucagon-Like Peptide 1MalePilot ProjectsProspective StudiesBile Acids and SaltsBlood GlucoseFatty Acids, VolatileGlucagon-Like Peptide 1

Identifiers

PMID40235083
PMCPMC12331552

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.