Evidence map›Paper›PMID 40235008›Full record

SynthesisEuropean journal of medical research2025

Analysis of the packing density of Hunter-Schreger bands (HSB): a systematic review and meta-analysis.

Mario Dioguardi, Eleonora Lo Muzio, Gaetano Illuzzi, Lorenzo Sanesi, Diego Sovereto, Andrea Ballini, Angela Pia Cazzolla, Angelo Martella, Lorenzo Lo Muzio

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mario DioguardiDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy. mario.dioguardi@unifg.it.
Eleonora Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.
Gaetano IlluzziDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.
Lorenzo SanesiDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.
Diego SoveretoDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.
Andrea BalliniDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.
Angela Pia CazzollaDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.
Angelo MartellaDataLab, Department of Engineering for Innovation, University of Salento, Lecce, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis review examines the different configuration of Hunter-Schreger bands (HSBs), focusing on the packing density of HSBs in various regions of the tooth crown, while also considering the clinical implications. This was achieved through a systematic analysis of the literature and by performing a meta-analysis and TSA (Trial Sequential Analysis).The systematic review was conducted following the PRISMA guidelines using electronic databases such as PubMed, Scopus, Cochrane Central Register of Controlled Trials, and ScienceDirect, with the use of combinations of keywords such as 'Hunter-Schreger bands' AND 'packing densities'. The meta-analysis was performed using RevMan 5.4 software.

resultsDuring the selection process, 190 records were identified, of which only 2 studies fully met the inclusion criteria, one of which presented data on packing densities in different areas of the tooth crown. The extracted data were included in the meta-analysis and TSA. The meta-analysis reported a mean difference (MD) of 4.95 [4.96, 5.22] for HSB packing density between the middle third and the cervical third of the enamel. In conclusion, HSB packing density is significantly higher in the middle region of the tooth crown, where greater occlusal forces occur. In contrast, the cervical regions, which have lower HSB density, are more susceptible to erosive and abrasive forces. These findings suggest that the spatial distribution of HSBs influences enamel resistance to mechanical stress and plays a role in the development of NCCLs.

Indexed as

Tooth CrownDental EnamelHumansDentalEnamelEnamel microstructureEnamel morphologyEnamel strengthHunter-SchregerNCCLTooth

Identifiers

PMID40235008
PMCPMC12001531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.