Evidence map›Paper›PMID 40234944›Full record

ArticleJournal of translational medicine2025

Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death.

Veronica Singh, Kyle T Wagner, Laura G Williams, Justin M Ryan, Katherine R Keller, Jonathan D Mohnkern, Robert S Gardner, Louis T Dang, Julie M Ziobro, Richard J H Wojcikiewicz and 2 more

Abstract read
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Veronica SinghDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Kyle T WagnerDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Laura G WilliamsDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Justin M RyanDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Katherine R KellerDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Jonathan D MohnkernDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Robert S GardnerDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Louis T DangDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Julie M ZiobroDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Richard J H WojcikiewiczDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Nathan R TuckerDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
David S AuerbachDepartment of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA. auerbacd@upstate.edu.ORCID 0000-0001-9198-3847

Funding

Mechanisms of PCDH19-clustering epilepsyK08NS124937 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie M Ziobro · 2023 to 2026
$976k
Development of a Genetic Rabbit Model of Kcnh2-Mediated Epilepsy, SUDEP, & Long QT Syndrome Type 2R61NS133273 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI AUERBACH, DAVID SCOTT · 2023 to 2024
$702k
Development of a Genetic Rabbit Model of Kcnh2-Mediated Epilepsy, SUDEP, & Long QT Syndrome Type 2R33NS133273 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI David Scott Auerbach · 2025 to 2026
$621k
American Epilepsy Society 060449-002American Heart Association 18CDA34110270NINDS NIH HHS 1R61NS133273NINDS NIH HHS K08 NS124937NINDS NIH HHS R33 NS133273NINDS NIH HHS R61 NS133273
6 · The paper itself

Abstract

backgroundLong QT Syndrome Type-2 (LQT2) is due to loss-of-function KCNH2 variants. KCNH2 encodes K

methodsWe generated the first knock-in rabbit model of LQT2 (Kcnh2

resultsMutant Kcnh2 is expressed in the heart and brain and constitutes 11% of total Kcnh2 in Kcnh2

conclusionsWe developed the first genetic rabbit model of LQT2 that reproduces the cardiac and epileptic phenotypes seen in people with LQT2. Kcnh2

Indexed as

Death, SuddenDeath, Sudden, CardiacEpilepsyERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsGene Knock-In TechniquesLong QT SyndromeAnimalsDisease Models, AnimalElectrocardiographyHumansRabbitsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsArrhythmiaEpilepsyKCNH2Long QT syndromeRabbitSeizureSUDEP

Identifiers

PMID40234944
PMCPMC12001650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.