Evidence map›Paper›PMID 40234933›Full record

ArticleBMC medicine2025

Relationship between multimorbidity, SARS-COV-2 infection and long COVID: a cross-sectional population-based French survey.

Tatjana T Makovski, Olivier Steichen, Melissa Rushyizekera, Marjan van den Akker, Joël Coste

Abstract read
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatjana T MakovskiDepartment of Non-Communicable Diseases and Injuries, French Public Health Agency (Sante Publique France), 12 Rue du Val d'Osne, Saint-Maurice Cedex, 94415, France. tatjana.makovski@santepubliquefrance.fr.ORCID http://orcid.org/0000-0002-3334-4809
Olivier SteichenUMR-S 1136, Sorbonne Universite, INSERM, Institut Pierre Louis d'Epidemiologie Et de Sante Publique, IPLESP, Paris, France.
Melissa RushyizekeraDepartment of Non-Communicable Diseases and Injuries, French Public Health Agency (Sante Publique France), 12 Rue du Val d'Osne, Saint-Maurice Cedex, 94415, France.
Marjan van den AkkerInstitute of General Practice, Goethe-University, Frankfurt, Frankfurt Am Main, Germany.
Joël CosteDepartment of Non-Communicable Diseases and Injuries, French Public Health Agency (Sante Publique France), 12 Rue du Val d'Osne, Saint-Maurice Cedex, 94415, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnderstanding the risks of COVID-19-related consequences for vulnerable groups such as people with multimorbidity is crucial to better tailor health care and public health measures. The main objective of this study was to explore the association between multimorbidity and WHO-defined post-COVID condition (PCC), while also considering the association with SARS-COV-2 infection given that the infection is a prerequisite of PCC.

methodsThis population-representative cross-sectional study was conducted in the general adult population in mainland France between 29 August and 31 December 2022 (N = 1813). The analyses of the association between multimorbidity (defined as disease count and most prevalent dyads/triads) and PCC or SAR-COV-2 infection were adjusted for age, sex, socioeconomic variables and number of infections (for PCC only) using adjusted Poisson regression with robust variance.

resultsThe study population had a mean age (SD) of 53 (± 18.5) years, while 53.6% were women. The likelihood of SARS-COV-2 infection increased with disease count but was only significant for ≥ 4 diseases. Five dyads and one triad presented a higher risk; almost all included anxiety. The likelihood of PCC increased with disease count, prevalence ratios (PRs) (95% CI) for 1, 2-3 and ≥ 4 diseases versus 0 were 1.90 (1.16-3.13), 3.32 (2.07-5.35) and 5.65 (3.41-9.38), respectively, and for 19 of 26 most prevalent dyads and the triad. The association was strongest for cardiac rhythm disorder and either low back pain (PR (95%CI) 4.17 (2.03-8.53)) or anxiety (PR (95%CI) 3.73 (1.98-7.01)).

conclusionsMultimorbidity, most frequently in combination with anxiety or low back pain, presented a significant association with PCC beyond that of SARS-CoV-2 infection underscoring the importance of implementing strategies to prevent and manage persistent symptoms in vulnerable groups.

Indexed as

COVID-19MultimorbidityAdultAgedCross-Sectional StudiesFemaleFranceHumansMaleMiddle AgedPost-Acute COVID-19 SyndromePrevalenceSARS-CoV-2FranceLong COVIDMultimorbidityMultiple conditionsPost COVID-19 conditionSARS-COV-2

Identifiers

PMID40234933
PMCPMC12001646

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.