Trial reportRadiation oncology (London, England)2025
Ultrahypofractionated partial breast irradiation following oncoplastic surgery: secondary analysis of a phase II trial.
Trial report in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Monitoring Pharmacological Treatment of Breast Cancer with MRI.Current issues in molecular biology · 2025Review
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough partial breast irradiation (PBI) is accepted as an effective and cosmesis-preserving technique for low-risk early-stage breast cancer following standard lumpectomy, data supporting PBI following oncoplastic surgery are sparse. We report prospective data in efforts to determine whether PBI can be safely utilized after oncoplastic surgery.
methodsPatients with low-risk stage 0-1 breast cancer following successful lumpectomy with optional oncoplastic reconstruction were enrolled on a phase II trial. Patients were treated with a modified Florence regimen to 30 Gy in 5 fractions on the Varian Edge radiosurgery system using IMRT or VMAT. Presurgical MRI, post-operative seroma and surgical clips were used to assist target delineation. The effect of oncoplastic surgery on radiation dosimetry and Breast Cancer Treatment Outcome Scale scores were assessed using student's t-test for continuous variables and chi-square for categorical variables.
resultsFrom 2018 to 2022, 50 patients with 52 tumors were enrolled with 48% undergoing oncoplastic reconstruction. Although median PTV volumes were numerically larger in the oncoplastic group (266 cc vs. 223 cc), there were no statistically significant differences in PTV volumes, ratio of PTV to whole breast or mean heart or lung doses (p > 0.05). Mean baseline BCTOS aesthetic scores were 1.35 for standard lumpectomy vs. 2.52 for oncoplastic (p = 0.003). At long-term follow-up > 2 years, mean BCTOS aesthetic scores were 1.29 for standard lumpectomy vs. 1.35 for oncoplastic (p = 0.71). At a median follow-up of 46 months, there were no local recurrences.
conclusionsWhen utilizing pre-treatment MRI, surgical clips and a relatively large PTV, PBI after oncoplastic surgery was safe and effective for appropriately selected patients. In combination with oncoplastic surgery, partial breast irradiation achieves excellent long-term cosmesis that improves over time.
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