Comparative evaluation of anterior segment optical coherence tomography and in vivo confocal microscopy for Kayser-Fleischer rings assessment in Wilson disease.

Jiao Tian, Xiuqin Yin, Yangyan Xiao

Abstract readObservational StudyComparative Study

In one paragraph

Observational study in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Jiao TianDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.

Xiuqin YinThe First Hospital of Changsha, Changsha, China.

Yangyan XiaoDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China. yyxiao@csu.edu.cn.

Funding

Hunan Provincial Medical Technology Innovation Guidance Project 2021SK53104National Natural Science Foundation of China 81700809National Natural Science Foundation of Hunan Province 2020JJ5839

6 · The paper itself

Abstract

objectiveTo compare the diagnostic accuracy of anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) in evaluating Kayser-Fleischer (KF) rings in patients with Wilson disease (WD). METHODS AND ANALYSIS: A prospective observational study enrolled 36 subjects (16 women) and 36 controls (16 women). All participants underwent both AS-OCT and IVCM, and the results were analyzed using McNemar's test to assess diagnostic concordancet.

resultsKF rings were not detected either with AS-OCT or with IVCM in any of the controls. Among the WD patients, seven subjects who did not show KF rings on AS-OCT were found to have them on IVCM (p < 0.05), six of whom were identified diagnosed with hepatic WD.

conclusionBoth AS-OCT and IVCM can provide objective assessment of KF rings. IVCM offers better accuracy compared to AS-OCT, particularly for hepatic WD.

Indexed as

Anterior Eye SegmentCorneal DiseasesHepatolenticular DegenerationTomography, Optical CoherenceAdolescentAdultChildFemaleHumansMaleMicroscopy, ConfocalMiddle AgedProspective StudiesReproducibility of ResultsYoung AdultAnterior segment optical coherence tomographyIn vivo confocal microscopyKayser–Fleischer ringsOphthalmic imaging

Identifiers

PMID40234809

DOI10.1186/s12886-025-04032-9

PMCPMC11998449

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