ArticleBMC gastroenterology2025
Frequency of insulin resistance among non-diabetic patients with non-alcoholic fatty liver disease using HOMA-IR: an experience of a tertiary care hospital in Karachi, Pakistan.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Noninvasive Detection of Clinically Significant Fibrosis in Biopsy-Proven MASLD: A Retrospective Cross-Sectional Diagnostic Accuracy Study.Medicina (Kaunas, Lithuania) · 2026Article
- Association of plasma homocysteine with the atherogenic index of plasma and modification by body mass index: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-alcoholic fatty liver disease (NAFLD) is a global problem strongly interlinked with metabolic syndrome. Insulin resistance (IR) is a key factor both in pathogenesis and in the progression to liver fibrosis. This article highlights the frequency of IR in local population.
objectiveTo determine the frequency and associated factors of insulin resistance among non-diabetic patients with NAFLD using HOMA-IR. MATERIALS AND
methodsA prospective cross-sectional study was conducted at Liaquat National Hospital, Karachi. 362 non-diabetic patients diagnosed with NAFLD were divided into two groups: with IR and without IR. Clinical history, physical examination, laboratory tests (fasting lipid profile, fasting glucose, insulin, liver function tests) and abdominal ultrasound with fibroscan for liver steatosis assessment were performed. Controlled Attenuation Parameter (CAP) score of ≥ 238 dB/m was used to define hepatic steatosis and metabolic syndrome was diagnosed based on specific clinical and laboratory criteria. Data was analyzed using SPSS version 27.
resultsTotal 362 patients were enrolled and 51.7% were male patients. 311(85.9%) participants had insulin resistance. Insulin resistance had significant difference for HDL, LDL, FPG, Fasting plasma insulin, and GGT. Male patients are less likely than female patients to exhibit insulin resistance. Insulin resistance is more common in patients with metabolic syndrome than in non-metabolic patients.
conclusionAmong non-diabetic patients with NAFLD, insulin resistance was highly prevalent and majority of patients were obese. Both genders were affected with IR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.