Evidence map›Paper›PMID 40234644›Full record

ArticleScientific reports2025

The inhibitory effect of Osthole on A549 lung adenocarcinoma cells and its biomarker.

Yinlan Xu, Lulu Chen, Dong Liu, Bo Xue, Chaoying Li, AJab Khan, Xuehua Li, Ruling Shi

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yinlan XuSchool of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan, China. xuyinlan2009@163.com.
Lulu ChenSchool of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Dong LiuSchool of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Bo XueSchool of Medical Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Chaoying LiSchool of Foreign Languages, Xinxiang Medical University, Xinxiang, 453003, China.
AJab KhanFaculty of Veterinary and Animal Sciences, The University of Agriculture, Dera Ismail Khan , 29050, Khyber Pakhtunkhwa, Pakistan.
Xuehua LiHenan Engineering Laboratory for Molecular Diagnosis of Animal Diseases, School of Life Sciences & Basic Medicine, Xinxiang University, Xinxiang, 453003, Henan, China.
Ruling ShiSchool of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan, China. 931017@xxmu.edu.cn.

Funding

Doctoral Research Funding of Xinxiang Medical College XYBSKYZZ202168Key Scientific and Technological Research Projects of Henan Province 222102310701Key Scientific Research Project of Colleges and Universities in Henan Province 23A320040National Natural Science Foundation of China U1904127
6 · The paper itself

Abstract

Some natural compounds derived from medicinal plants show anti-tumor activity with high efficacy and safety, low toxicity and residual levels etc. The aim of this study was to select natural compounds and biomarkers having high inhibitory effects against A549 adenocarcinoma cells. A total of eight natural compounds having pure plant origin were initially screened, purchased, and their potential anti-cancer activities were comprehensively and systematically evaluated against A549 lung adenocarcinoma cells. The maximum non-cytotoxic concentration (MNTC) and 50% cytotoxic concentration (CC

Indexed as

Adenocarcinoma of LungAntineoplastic Agents, PhytogenicBiomarkers, TumorCoumarinsLung NeoplasmsA549 CellsApoptosisCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansReactive Oxygen SpeciesAntineoplastic Agents, PhytogenicBiomarkers, TumorCoumarinsostholReactive Oxygen SpeciesA549Adenocarcinoma cellsApoptosisEMTOstholeRNA-seq

Identifiers

PMID40234644
PMCPMC12000571

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.