ArticleNature human behaviour2025
Charting brain functional development from birth to 6 years of age.
Article in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Division-Specific Organization of a Shared Functional Scaffold in the Early-Life Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- Age at diagnosis of strabismus or amblyopia and neurodevelopmental outcomes in children.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Explicitly nonlinear fMRI networks reveal hidden trajectories of infant brain development.bioRxiv : the preprint server for biology · 2026Article
- The Impact of Diabetes on Brain Health in Childhood.Biomedicines · 2026Review
- Early life phthalate and replacement plasticizer exposures and changes in early childhood brain functional connectivity and structural morphology.Environment international · 2026Article
- Predictive associations between brain functional connectivity, motor abilities, and executive function development in early childhood: a longitudinal machine learning study.Journal of neuroengineering and rehabilitation · 2026Article
- Hierarchical maturation of structural brain connectomes from birth to childhood.Nature communications · 2026Article
- LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Convergent and divergent spatial topographies of individualized brain functional networks and their developmental origins.Psychoradiology · 2026Article
- From rest to meaning: default mode network neuroscience as a design constraint for early childhood education.Frontiers in psychology · 2026Review
- Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Physical Activity and Its Effects on Executive Functions and Brain Outcomes in Children: A Narrative Review.Brain sciences · 2025Review
- Spatial development of brain networks during the first six postnatal months.Communications biology · 2025Article
- Developmental alterations in brain network asymmetry in 3- to 9-month infants with congenital sensorineural hearing loss.Science advances · 2025Article
- Nervonic acid in infant nutrition: a forward-looking approach to enhancing neurodevelopmental outcomes.Frontiers in nutrition · 2025Review
- Sex-specific associations of gestational age at birth and birth size with early life within-network brain connectivity: An exploratory study.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Early childhood is crucial for brain functional development. Using advanced neuroimaging methods, characterizing functional connectivity has shed light on the developmental process in infants. However, insights into spatiotemporal functional maturation from birth to early childhood are substantially lacking. In this study, we aggregated 1,091 resting-state functional MRI scans of typically developing children from birth to 6 years of age, harmonized the cohort and imaging-state-related bias, and delineated developmental charts of functional connectivity within and between canonical brain networks. These charts revealed potential neurodevelopmental milestones and elucidated the complex development of brain functional integration, competition and transition processes. We further determined that individual deviations from normative growth charts are significantly associated with infant cognitive abilities. Specifically, connections involving the primary, default, control and attention networks were key predictors. Our findings elucidate early neurodevelopment and suggest that functional connectivity-derived brain charts may provide an effective tool to monitor normative functional development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.