Evidence map›Paper›PMID 40234527›Full record

ArticleScientific reports2025

LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma.

Tatiana Blanchard, Pouya Faridi, Chong Xu, Adham S Bear, Reyaz Ur Rasool, Grace Huang, Terry C C Lim, Rochelle Ayala, Khatuna Gabunia, Mei Ji and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tatiana BlanchardDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Pouya FaridiCentre for Cancer Research, Hudson Institute of Medical Research, Monash University, Clayton, VIC, 3168, Australia.
Chong XuCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Adham S BearDivision of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Reyaz Ur RasoolDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.
Grace HuangCentre for Cancer Research, Hudson Institute of Medical Research, Monash University, Clayton, VIC, 3168, Australia.
Terry C C LimCentre for Cancer Research, Hudson Institute of Medical Research, Monash University, Clayton, VIC, 3168, Australia.
Rochelle AyalaDepartment of Biochemistry and Molecular Biology and Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Khatuna GabuniaCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mei JiCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Avery D PoseyDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John SchollerCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Irfan A AsanganiDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.
Anthony W PurcellDepartment of Biochemistry and Molecular Biology and Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Gerald P LinetteCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carl H JuneCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Beatriz M CarrenoCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bcarreno@upenn.edu.

Funding

Physician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5M
Project 3U54CA244711 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JUNE, CARL H. · 2019 to 2022
$7.1M
Towards characterization of Epigenetic targets in Prostate CancerR01CA299870 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Irfan Ahmed Asangani · 2025 to 2026
$722k
National Health and Medical Research Council 2016596NCI NIH HHS K12 CA076931NCI NIH HHS R01 CA299870NCI NIH HHS U54 CA244711NIH HHS K12CA076931NIH HHS T32CA099140NIH HHS U54CA244711Victorian Cancer Agency 2001870
6 · The paper itself

Abstract

Ewing Sarcoma (EwS) is a rare pediatric malignancy characterized by a unique t(11:22) (q24;q12) translocation resulting in the pathognomonic EWSR1::FLI1 fusion. Recent reports indicate that the EWSR1::FLI1 oncofusion drives aberrant expression of numerous transcripts, including Lipoxygenase Homology Domains 1 (LOXHD1). Given its highly restricted protein expression pattern and role in EwS tumorigenesis and metastasis, LOXHD1 may serve as a novel immunotherapeutic target in this malignancy. LOXHD1 immunogenic epitopes restricted to HLA-A*02:01 allowed for the isolation of a high avidity αβTCR. LOXHD1-specific TCR engineered CD8

Indexed as

Antigens, NeoplasmSarcoma, EwingAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansMiceOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSAntigens, NeoplasmOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWS

Identifiers

PMID40234527
PMCPMC12000433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.