ArticleScientific reports2025
Anterior tenting vs. whole wrapping technique for acellular dermal matrix in breast reconstruction under post-mastectomy radiotherapy in rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this experimental study, we compared the outcomes between anterior-tenting and wrapping techniques in prepectoral breast reconstruction using an acellular dermal matrix (ADM). Fifteen rats were divided into control, anterior-tenting, and whole-wrapping groups, each receiving two silicone implants. In the control group, only silicone implants were placed, whereas in the anterior-tenting and whole-wrapping groups, the anterior surface of the implants and the entire implants were covered with ADM, respectively. The Animals were irradiated on one side of the back 3 weeks postoperatively and sacrificed 3 months postoperatively. The range of change in tonometry values with or without irradiation in the whole-wrapping group tended to be larger than that in the anterior-tenting group (p < 0.05). The cellular capsule was significantly thinner on the side covered by ADM (p < 0.05). There were no significant differences in other microscopic features of the cellular capsule. Microscopic analysis of the ADM revealed significant increases in thickness and collagen density with radiation exposure, whereas a significant decrease was observed in the α-smooth muscle actin-positive area, CD3-positive cell counts, and F4/80 positive area (p < 0.05). In our rat model, the whole wrapping technique led to a greater increase in intraprosthetic pressure due to radiation-related structural changes in ADM, compared to the anterior-tenting technique.
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