ArticleNature communications2025
Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Article
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Galactic cosmic radiation produces sex-specific, circuit-selective cognitive vulnerability: countermeasure trade-offs revealed by multi-domain assessment.Research square · 2026Article
- Dpp6 knockout mice exhibit increased ethanol conditioned place preference and acute ethanol-induced anxiolytic behavior.Alcohol, clinical & experimental research · 2026Article
- Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus.Frontiers in systems neuroscience · 2026Review
- Neural mechanisms of food preference and reward processing: a review of multifaceted influencing factors and intervention strategies.Frontiers in nutrition · 2026Review
- Sex Differences in the Ventral Subiculum's Microcircuitry and Function.Hippocampus · 2026Review
- Down-regulation of gastrin-releasing peptide in medial orbitofrontal cortex to nucleus accumbens projections contributes to allodynia and negative affect.Science advances · 2025Article
- 7T multimodal MRI reveals structural-functional-quantitative susceptibility mapping abnormalities of new daily persistent headache.The journal of headache and pain · 2025Article
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus accumbens, a highly integrative brain region controlling motivated behavior, receives various glutamatergic inputs, yet the relative functional specialization of these inputs is unclear. While circuit neuroscience commonly seeks specificity, redundancy can be highly adaptive and is a critical motif in circuit organization. Using dual-site fiber photometry in an operant reward task in mice, we simultaneously recorded from two accumbal glutamatergic afferents to assess circuit specialization. We identify a common neural motif integrating reward history in medial prefrontal cortex and ventral hippocampus inputs. By systematically degrading task complexity, dissociating reward from choice and action, we identify circuit-specificity in the behavioral conditions that recruit encoding. While input from the prefrontal cortex invariantly encodes reward, encoding in ventral hippocampal input is uniquely anchored to unrewarded outcomes. Optogenetic stimulation demonstrates that both inputs co-operatively modulate task engagement. We illustrate how similar encoding, differentially gated by behavioral state, supports state-sensitive tuning of reward-motivated behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.