ArticleNature communications2025
A modular artificial intelligence framework to facilitate fluorophore design.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Multiobjective Fluorescent Molecule Design with a Data-Physics Dual-Driven Generative Framework.JACS Au · 2026Article
- Integrating Low-Cost xTB Electronic Priors for Predicting Electronic and Excited-State Properties of Organic Conjugated Molecules.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Freezing-Induced Spatial Confinement During Cryo-Polymerization Enables Stable Intrinsic Luminescence in Hydrogels.Angewandte Chemie (International ed. in English) · 2026Article
- Bioresorbable and optically readable triboelectric implants enabled by nanoscale iridophosphors.Nature nanotechnology · 2026Article
- Artificial Intelligence for Discovery in Life Sciences.Bioconjugate chemistry · 2026Review
- A Contrastive-Learning-Based Pre-Training Framework for Optical Property Prediction of Low-Data Rhodamines with Interpretable Multitask Graph Neural Networks.Molecules (Basel, Switzerland) · 2026Article
- Recent Progress in Gain Materials for Microlasers and Modern Digital Approaches for Biophotonics: From Dyes to Semiconductors.Micromachines · 2026Review
- AI-Driven Acceleration of Fluorescence Probe Discovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Machine Learning-Driven Design of Fluorescent Materials: Principles, Methodologies, and Future Directions.Nanomaterials (Basel, Switzerland) · 2025Review
- Deep Learning-Driven Intelligent Fluorescent Probes: Advancements in Molecular Design for Accurate Food Safety Detection.Foods (Basel, Switzerland) · 2025Review
- A modular artificial intelligence framework to facilitate fluorophore design.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Fluorescence imaging, indispensable for fundamental research and clinical practice, has been driven by advances in fluorophores. Despite fast growth over the years, many available fluorophores suffer from insufficient performances, and their development is highly dependent on trial-and-error experiments due to subtle structure-property effects and complicated solvent effects. Herein, FLAME (FLuorophore design Acceleration ModulE), an artificial intelligence framework with a modular architecture, is built by integrating open-source databases, multiple prediction models, and the latest molecule generators to facilitate fluorophore design. First, we constructed the largest open-source fluorophore database to date (FluoDB), containing 55,169 fluorophore-solvent pairs. Then FLSF (FLuorescence prediction with fluoroScaFfold-driven model) with a domain-knowledge-derived fingerprint for characterizing fluorescent scaffolds (called fluoroscaffold) was designed and demonstrated to predict optical properties quickly and accurately, whose reliability and potential have been verified via molecular and atomistic interpretability analysis. Further, a molecule generator was incorporated to provide new compounds with desired fluorescence. Representative 3,4-oxazole-fused coumarins were synthesized and evaluated, creating an unreported compound with bright fluorescence.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.