ArticleNature communications2025
Electrocatalytic N-C-N coupling over a hierarchically ordered open single-atom superstructure toward organonitrogen synthesis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Electrocatalytic and Photocatalytic C─N Coupling From Small Molecules.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Redox-mediated domino electrosynthesis of N,N-dimethylformamide with industrial-relevant productivity and modularized cathodic integration.Nature communications · 2026Article
- Hierarchically Porous Nitrogen-Doped Carbon with High Conductivity for Rapid and Efficient Cr(VI) Reduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Electrochemical Approach to Organonitrogen Compounds via C-N Coupling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Electrochemically constructing C-N and N-C-N bonds provides an economical and sustainable alternative to conventional chemosynthesis. Herein, a hierarchically ordered open superstructure of N-doped carbon isolated with accessible three-coordinated Zn single-atom sites is explored for efficient electrocatalytic N-C-N coupling. Benefiting from the distinctive structural merits, this catalyst enables electrocatalytic preparation of N-C-N bonded compounds from methanol and amines. Notably, the Faradaic efficiency and selectivity of N,N,N',N'-tetramethyldiaminomethane reach up to 77% and 96% at 0.8 V, respectively. Further integrating the aminoalkylation reaction, an electro-thermo cascade synthesis is explored with the electrochemically obtained N,N,N',N'-tetramethyldiaminomethane serving as a unique reagent, leading to a specific set of organonitrogen compounds with (dimethylamino)methyl substituent, including topotecan hydrochloride, an anti-tumor drug, with a high yield of 95%. Furthermore, the in situ spectroscopic characterization and calculations unveil that the under-coordinated Zn-N
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Registered trials
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