Evidence map›Paper›PMID 40234403›Full record

ArticleNature communications2025

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy.

Daisuke Yoshinaga, Isabel Craven, Rui Feng, Maksymilian Prondzynski, Kevin Shani, Yashasvi Tharani, Joshua Mayourian, Milosh Joseph, David Walker, Raul H Bortolin and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Cells · 2025
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Daisuke YoshinagaDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Isabel CravenDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rui FengDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Maksymilian ProndzynskiDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kevin ShaniDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences, Allston, MA, USA.
Yashasvi TharaniDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3551-3362
Joshua MayourianDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Milosh JosephDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
David WalkerDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Raul H BortolinDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Chrystalle Katte CarreonDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Bridget BossDepartment of Pediatric Cardiology, Dartmouth Hitchcock Medical Center, Manchester, NH, USA.
Sheila UptonDepartment of Medical Genetics, Dartmouth Hitchcock Medical Center, Manchester, NH, USA.
Kevin Kit ParkerDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences, Allston, MA, USA.ORCID http://orcid.org/0000-0002-5968-7535
William T PuDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4551-8079
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Vassilios.Bezzerides@cardio.chboston.org.ORCID http://orcid.org/0000-0003-0825-6580

Funding

The role N-terminal acetylation in dilated cardiomyopathy and associated arrhythmiaR01HL164710 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Vassilios James Bezzerides · 2023 to 2026
$2.9M
Novel molecular therapies for CPVTK08HL140197 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BEZZERIDES, VASSILIOS JAMES · 2018 to 2022
$851k
NHLBI NIH HHS K08 HL140197NHLBI NIH HHS R01 HL164710U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R01HL164710
6 · The paper itself

Abstract

N-terminal acetyltransferases including NAA10 catalyze N-terminal acetylation, an evolutionarily conserved co- and post-translational modification. However, little is known about the role of N-terminal acetylation in cardiac homeostasis. To gain insight into cardiac-dependent NAA10 function, we studied a previously unidentified NAA10 variant p.(Arg4Ser) segregating with QT-prolongation, cardiomyopathy, and developmental delay in a large kindred. Here, we show that the NAA10

Indexed as

Arrhythmias, CardiacCardiomyopathiesN-Terminal Acetyltransferase AN-Terminal Acetyltransferase EAcetylationAnimalsFemaleHumansInduced Pluripotent Stem CellsMaleMyocytes, CardiacPedigreeProtein Processing, Post-TranslationalNAA10 protein, humanN-Terminal Acetyltransferase AN-Terminal Acetyltransferase E

Identifiers

PMID40234403
PMCPMC12000442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.