Evidence map›Paper›PMID 40234341›Full record

ArticleGeroScience2026

Prospective association of depression symptoms with exceptional longevity among older women.

Carlos E Rosas, Steve Nguyen, Aladdin H Shadyab, Ariana M Stickel, Shawnita Sealy-Jefferson, Michelle J Naughton, Lorena Garcia, Linda C Gallo, Andrea Z LaCroix

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlos E RosasHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA. cerosas@sdsu.edu.ORCID 0000-0003-1468-5242
Steve NguyenHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
Ariana M StickelDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Shawnita Sealy-JeffersonCollege of Public Health, The Ohio State University, Columbus, OH, USA.
Michelle J NaughtonDivision of Cancer Prevention and Control, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Lorena GarciaDivision of Epidemiology, Public Health Sciences, University of California Davis School of Medicine, Davis, CA, USA.
Linda C GalloSouth Bay Latino Research Center, San Diego State University, San Diego, CA, USA.
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.

Funding

Improving the Health of Aging Women and Men.T32AG058529 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACROIX, ANDREA Z. · 2019 to 2023
$1.2M
Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's BiomarkersK08AG075351 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariana Stickel · 2022 to 2026
$770k
Plasma proteomic signatures of physical activity and Alzheimer's disease and related dementiasK99AG082863 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, STEVE · 2023 to 2024
$206k
National Institute of Health (US) U54CA267789NCATS NIH HHS 1UM1 TR004407-02NHLBI NIH HHS HHSN268201100001CNHLBI NIH HHS HHSN26820-1100002CNHLBI NIH HHS HHSN268201100003CNHLBI NIH HHS HHSN26820-1100004CNHLBI NIH HHS HHSN268-201100046CNHLBI NIH HHS HHSN271201100004CNIA NIH HHS 5T32AG058529NIA NIH HHS 5T32AG058529-04NIA NIH HHS K08 AG075351NIA NIH HHS K08AG075351NIA NIH HHS K99AG082863NIA NIH HHS T32 AG058529NIDDK NIH HHS TL1DK143272-01
6 · The paper itself

Abstract

Older women may experience elevated depression symptoms, which have been associated with morbidity and mortality. Yet, few studies have examined associations of depression symptoms with longevity. We examined associations among older women of depression symptoms with survival to ages 90, 95, and 100, and survival to age 90 with intact mobility and cognitive functioning. Participants were 70,560 women enrolled in the Women's Health Initiative with potential, due to birth year, to reach age ≥ 90 as of February 2022. Depression symptoms were assessed at baseline (1993-1998) using the Burnam screen, which comprises the 6-item Center for Epidemiologic Studies Depression Scale and 2 items from the Diagnostic Interview Schedule. Depression symptoms were classified as elevated (vs. not) using an established cut point of ≥ 0.06 for detecting depressive disorders. Survival (vs. death) to ages 90, 95, and 100 years was assessed. Among women surviving to age ≥ 90, maintenance of mobility and cognitive function were assessed in relation to depression symptoms. A total of 37,460 women (53.1%) survived to age ≥ 90. Women with (vs. without) elevated depression symptoms had 15% lower odds of surviving to age 90, 18% lower odds of surviving to age 95, and 23% lower odds of surviving to age 100. Among women surviving to 90, those with (vs. without) elevated depression symptoms had 46% lower odds of surviving with intact mobility and cognition. Depression symptoms associated with lower odds of healthy longevity. Findings underscore importance of depression intervention to increase women's odds of healthy longevity.

Indexed as

DepressionLongevityAgedAged, 80 and overCognitionFemaleHumansProspective StudiesUnited StatesDepressionLongevityMental healthOldest old

Identifiers

PMID40234341
PMCPMC12972379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.