ArticlePurinergic signalling2025
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling.
Article in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association of Physical Activity Levels with Severe Multimorbidity Among Middle-Aged and Older Adults: Evidence from CHARLS and a Community Sample.Healthcare (Basel, Switzerland) · 2026Article
- Cytokine Profiles as Molecular Markers Associated with Physical Exercise and Insulin Therapy in Patients with Type 2 Diabetes Mellitus.Current issues in molecular biology · 2026Article
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Authors and funding
10 authors.
Funding
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Abstract
This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory profiles in sedentary women with type 2 diabetes mellitus (T2DM). Over 16 weeks, participants underwent a combined aerobic and resistance training program. The intervention resulted in reduced extracellular ATP levels and decreased activity of E-NTPDase and ADA enzymes, shifting the inflammatory balance toward an anti-inflammatory profile. A significant increase in anti-inflammatory cytokines (IL-10, IL-4) and a decrease in pro-inflammatory markers (TNF-α, IFN-γ, IL-6) were observed in the T2DM group. Correlations indicated that ATP hydrolysis was inversely related to anti-inflammatory cytokines, supporting the role of PE in modulating purinergic pathways. Additionally, improvements in glycemic control, systolic blood pressure, and functional capacity highlighted the systemic benefits of exercise. These findings emphasize the therapeutic potential of PE in managing T2DM by targeting inflammation and metabolic dysregulation through purinergic modulation. Further studies should explore these mechanisms to optimize exercise-based interventions.
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