Evidence map›Paper›PMID 40234285›Full record

SynthesisNeurosurgical review2025

Surgical management and outcomes of ankylosing spondylitis fractures in adults: a systematic review and meta-analysis.

Asfand Baig Mirza, Feras Fayez, Sami Rashed, Ariadni Georgiannakis, Pak Yin Lam, Aleksander Lysomirski, Chaitanya Sharma, Zekiye Karagozlu, Amisha Vastani, Christoforos Syrris and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Asfand Baig MirzaNeurosurgery Department, Queens Hospital, Romford, UK. Asfand.mirza@nhs.net.
Feras FayezNorth East London and Essex (NELE) Spine Network, London, UK.
Sami RashedNeurosurgery Department, Queens Hospital, Romford, UK.
Ariadni GeorgiannakisNorth East London and Essex (NELE) Spine Network, London, UK.
Pak Yin LamGKT School of Medical Education, King's College London, London, UK.
Aleksander LysomirskiBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Chaitanya SharmaGKT School of Medical Education, King's College London, London, UK.
Zekiye KaragozluImperial College School of Medicine, Imperial College London, London, UK.
Amisha VastaniCharring Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.
Christoforos SyrrisDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Irfan MalikDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Gordan GrahovacDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Alexander MontgomeryNorth East London and Essex (NELE) Spine Network, London, UK.
Taofiq Desmond SanusiNeurosurgery Department, Queens Hospital, Romford, UK.
Babak ArvinNeurosurgery Department, Queens Hospital, Romford, UK.
Ahmed Ramadan SadekNeurosurgery Department, Queens Hospital, Romford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnkylosing spondylitis (AS) is a chronic inflammatory condition affecting the vertebral column. Surgical management of traumatic spinal fractures in patients with AS is often the first line treatment, however it has a high risk of perioperative complications. This systematic review explored current operative techniques and their outcomes in patients with AS sustaining traumatic spinal fractures.

methodsA PRISMA-compliant systematic review was conducted, and databases Embase, Pubmed/Medline and Cochrane were searched from inception to April 2024. Studies were included if they had complete individual patient data. Data was synthesized qualitatively and quantitatively. Univariate and multivariate logistic regression and ordinal regression was performed on R, to evaluate the relationship between surgical outcomes and independent patient and operative factors.

resultsSeven studies with complete individual patient data were included, involving 150 patients. Increasing age was a significant predictor of mortality (OR 1.08, 95% CI 1.04-1.13, p < 0.001) and post-operative complications (OR 1.07, 95% CI 1.04-1.10, p < 0.001). Fixation and decompression of the thoracic level was also strongly associated with higher complications (OR 6.4, 95% CI 1.28-40.14, p < 0.05). Single level compression improved post-operative ASIA outcomes (OR 0.43, 95% CI 0.17-0.97, p < 0.05). A higher pre-operative ASIA score (C, D or E) was related with improved post-operative neurological recovery.

conclusionThis study emphasizes the impact of age, level of spinal involvement, and surgical approach on surgical outcomes of traumatic spine fractures in AS. Future randomised controlled trials in the field can help further refine surgical strategies and improve patient care.

Indexed as

Spinal FracturesSpondylitis, AnkylosingAdultDecompression, SurgicalHumansPostoperative ComplicationsTreatment OutcomeAnkylosing spondylitisASIA scoreSurgical managementSystematic reviewTraumatic spinal fractures

Identifiers

PMID40234285

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.