Evidence map›Paper›PMID 40234258›Full record

ArticlePediatric cardiology2026

Feasibility of an Individualized Exercise Training Program for Children with Hypertrophic Cardiomyopathy.

Julianne Wanner, Danielle Burstein, Stephen Paridon, Maully Shah, Shannon O'Malley, Kimberly Y Lin, Jonathan B Edelson

Abstract read
In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julianne WannerDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Danielle BursteinDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Stephen ParidonDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Maully ShahDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Shannon O'MalleyDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Kimberly Y LinDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
Jonathan B EdelsonDivision of Cardiology, The Children'S Hospital of Philadelphia, Philadelphia, PA, USA. edelsonj@email.chop.edu.ORCID http://orcid.org/0000-0003-3220-7922

Funding

MIGHTIER: Movement in Heart Transplant patients: the Impact of Environmental factoRsK23HL169833 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Jonathan Buniva Edelson · 2024 to 2026
$482k
NHLBI NIH HHS K23 HL169833
6 · The paper itself

Abstract

Limited data exist to guide exercise participation in pediatric hypertrophic cardiomyopathy (HCM) patients. Exercise is traditionally restricted in this population, despite research in adults with HCM demonstrating exercise-associated cardiovascular and psychological benefit. This pilot study seeks to assesses the safety and feasibility of a moderate-intensity exercise program in children with HCM to guide future study design. Eight subjects ages 8-18 with HCM were recruited from the outpatient cardiology clinic at a large tertiary care referral center. All subjects were NYHA Class I (n = 4) or II (n = 4) and median septal wall thickness was 2.3 cm [IQR 1.4, 2.5]. The intervention included a 16-week exercise program, consisting of three 30-min aerobic and two strength sessions per week. A target heart rate zone was established using a baseline cardiopulmonary exercise test (CPET). A FitBit device was used to titrate activity to this zone during sessions. Self-reported adherence ranged from 1.25 to 96.25%. At baseline, cardiorespiratory fitness, assessed by CPET, and Health Related Quality of Life (HRQoL), assessed using two validated instruments, were reduced compared to peers. All subjects (n = 4) who completed the intervention improved in exercise performance and HRQoL measures. Ambulatory rhythm monitoring did not reveal any intervention-related arrhythmias, and there were no cardiac adverse events. This pilot study shows the promise of a potential benefit of an interventional exercise program in children with HCM. Future work should aim to improve retention, and more fully assess the safety and impact of exercise in pediatric HCM.

Indexed as

Cardiomyopathy, HypertrophicExercise TherapyAdolescentCardiorespiratory FitnessChildExercise TestFeasibility StudiesFemaleHumansMalePilot ProjectsQuality of LifeExerciseHypertrophic cardiomyopathyPediatricQuality of life

Identifiers

PMID40234258
PMCPMC12855382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.