Evidence map›Paper›PMID 40234153›Full record

ArticleUltrasound in medicine & biology2025

Homodyned K-Distribution Temporal-Based Characterization of Rat Placenta Microstructure Using the Reduced Uterine Perfusion Pressure Model of Preeclampsia.

Alexander D Gleed, Andrew C Markel, Lili Shi, Allan K N Alencar, Kenneth F Swan, Cameron Hoerig, Gabriella C Pridjian, Carolyn L Bayer, Jonathan Mamou

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In one paragraph

Article in Ultrasound in medicine & biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Alexander D GleedDepartment of Radiology, Weill Cornell Medicine, New York City, NY, USA. Electronic address: adg4005@med.cornell.edu.
Andrew C MarkelDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Lili ShiDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Allan K N AlencarDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Kenneth F SwanDepartment of Obstetrics and Gynecology, Tulane University, New Orleans, LA, USA.
Cameron HoerigDepartment of Radiology, Weill Cornell Medicine, New York City, NY, USA.
Gabriella C PridjianDepartment of Obstetrics and Gynecology, Tulane University, New Orleans, LA, USA.
Carolyn L BayerDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Jonathan MamouDepartment of Radiology, Weill Cornell Medicine, New York City, NY, USA.

Funding

Quantitative Ultrasound for Assessment of Placental Structure During the Development of PreeclampsiaR21HD114007 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE, MAMOU, JONATHAN · 2023 to 2023
$443k
NICHD NIH HHS R21 HD114007
6 · The paper itself

Abstract

objectiveWe characterize rat placenta microstructure in the context of the reduced uterine perfusion pressure (RUPP) model of preeclampsia using the homodyned K-distribution to parameterize envelope-detected signals of ultrasound radiofrequency echo frames obtained in vivo. Preeclampsia is a life-threatening pregnancy syndrome related to abnormal placental tissue microstructure which motivated the quantitative ultrasound-based tissue characterization approach used in this study.

methodsUltrasound radiofrequency echo frames against time (or videos) were obtained on 30 and 38 in vivo placentae at gestation day (GD) 14 and 18 respectively, using 9 Sprague-Dawley rats. Preeclampsia-like effects were induced by surgical modification (post GD 14) following the RUPP model, giving a total of 20 RUPP and 18 control placentae at GD 18. The homodyned K-distribution was fit to value distributions of envelope-detected signals of ultrasound radiofrequency echo frames against time, yielding temporal α (scatterer number per resolution cell) and κ (ratio of coherent to diffuse signal power) parameters used to characterize the placental tissue microstructure.

resultsVisualization of GD 18 α values as a color overlay on B-mode ultrasound video suggested higher values of control compared with RUPP. The mean kurtosis for RUPP was 4.07 ± 0.71 in comparison to 5.08 ± 1.28 for the control using placenta-level kurtosis values (p = 0.0044). There were no significant differences observed in GD 14 placentae, consistent with expectations. Further, we visualized and quantified temporal changes in GD 18 α values with frame-level statistics that support earlier findings.

conclusionsThis study quantitatively characterizes rat placenta microstructure using the homodyned K-distribution and temporal α and κ parameters.

Indexed as

PlacentaPre-EclampsiaUterusAnimalsDisease Models, AnimalFemalePregnancyRatsRats, Sprague-DawleyUltrasonographyHomodyned K-distributionPlacentaPreeclampsiaQuantitative ultrasoundTemporalUltrasoundVideo

Identifiers

PMID40234153
PMCPMC12103998

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