Evidence map›Paper›PMID 40234095›Full record

ArticleExperimental neurobiology2025

Magnesium-L-threonate Ameliorates Cognitive Deficit by Attenuating Adult Hippocampal Neurogenesis Impairment in a Mouse Model of Alzheimer's Disease.

Ying Xiong, Yuwen Yang, Yuting Ruan, Wencai Ou, Zhiwen Hu, Wei Li, Nina Xiao, Wang Liao, Jianhua Liu, Zhenlu Liu and 3 more

Abstract read
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In one paragraph

Article in Experimental neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ying XiongDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Yuwen YangDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Yuting RuanDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Wencai OuDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Zhiwen HuDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Wei LiDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Nina XiaoDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Wang LiaoDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Jianhua LiuDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Zhenlu LiuDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Qiong LuoDepartment of Medical Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510000, China.
Feifei LiuDepartment of Medical Ultrasound, Xiang'an Hospital of Xiamen University, Xiamen 361000, China.
Jun LiuDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired adult hippocampal neurogenesis is a key pathological mechanism contributing to memory deficits in Alzheimer's disease (AD). Recent studies have shown that elevating magnesium levels promotes neurogenesis by enhancing the neuronal differentiation of adult neural progenitor cells in vitro. Therefore, this in vivo study aims to determine if magnesium-L-threonate (MgT) can ameliorate cognitive deficit of AD mice by attenuating adult hippocampal neurogenesis impairment and to reveal the underlying mechanisms. APPswe/PS1dE9 mice were treated with different doses of MgT and ERK inhibitor PD0325901. The memory ability of each mouse was recorded by Morris Water Maze test. After cognitive test, hippocampus tissues were collected to measure the proportion of BrdU/doublecortin double-labeled cells using the flow cytometry test and assess the expression of doublecortin using PCR and Western blot. Furthermore, the activations of CREB, ERK, P38 and JNK were measured by Western blot to identify the involved mechanisms. The cognitive test confirmed that MgT treatment attenuated the memory impairment of APPswe/PS1dE9 mice. Flow cytometry test showed that Brdu/doublecortin labeled newborn neurons gradually increased following MgT administration. In line with the flow cytometry results, Western blot and PCR confirmed that MgT administration significantly increased doublecortin expression levels. Furthermore, the ratios of p-ERK/ERK and p-CREB/CREB increased with MgT elevation. In addition, these effects of MgT treatment were markedly reversed by PD0325901 supplementation. In conclusion, MgT treatment improved cognitive decline by ameliorating adult hippocampal neurogenesis impairment in this AD model, possibly via ERK/CREB activation.

Indexed as

Alzheimer’s diseaseCognitive declineMagnesiumNeurogenesis

Identifiers

PMID40234095
PMCPMC12069926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.