ArticleJournal of clinical periodontology2025
Macrophage Depletion Reduces Bone Loss and Alters Inflammatory Responses: A Mouse Peri-Implantitis Model.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation.International journal of implant dentistry · 2026Review
- Mitochondrial dysfunction in peri-implantitis: bioinformatics and machine learning analysis with in vivo experiment.Odontology · 2026Article
- Tissue-specific adaptation of human T cells is preserved during tissue inflammation.bioRxiv : the preprint server for biology · 2026Article
- Extracellular Vesicles as Orchestrators of Osteoimmunomodulation in Peri-Implantitis: Implications for Bone Regeneration.Clinical implant dentistry and related research · 2026Review
- Peri-Implant Diseases: The Past, the Present, the Future.Journal of periodontal research · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimTo evaluate the impact of macrophage depletion on bone loss and inflammatory responses in a mouse model of peri-implantitis, assessing macrophage depletion potential as a therapeutic strategy. MATERIALS AND
methodsUsing 6-week-old male C57BL/6 mice, peri-implantitis was induced by placing a silk ligature around osteointegrated dental implants. Mice were divided into three groups: Healthy control (Healthy group); peri-implantitis with liposomal phosphate-buffered saline (PBS group); and peri-implantitis with liposomal clodronate for macrophage depletion (CLOD group). Two weeks after ligature placement, micro-CT, histological and real-time PCR analyses were performed to assess bone density, leukocyte infiltration and cytokine levels.
resultsThe CLOD group showed a significantly higher bone-to-implant contact (74%) and bone volume relative to total volume (79%) compared to the PBS group (53% and 54%, respectively) and Healthy group (64% and 66%, respectively). Histological analysis revealed significantly reduced leukocyte and macrophage counts in the CLOD group. Additionally, TNF-α and IL-10 levels were significantly decreased in the CLOD group compared with the PBS group.
conclusionMacrophage depletion effectively reduces bone loss and inflammation in peri-implantitis. This study highlights targeting macrophages as a promising approach for managing peri-implantitis, although further research is needed to optimize therapeutic strategies.
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