Evidence map›Paper›PMID 40234005›Full record

Trial reportThorax2025

The impact of dosage timing for inhaled corticosteroids in asthma: a randomised three-way crossover trial.

Ran Wang, Robert Maidstone, Dave Singh, David Ray, Andrew S Loudon, Angela Simpson, Hannah Jane Durrington

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ran WangNIHR Manchester Biomedical Research Centre, Manchester, UK.
Robert MaidstoneSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-3482-3246
Dave SinghNIHR Manchester Biomedical Research Centre, Manchester, UK.
David RayNIHR Oxford Biomedical Research Centre, Oxford, UK.
Andrew S LoudonSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Angela SimpsonNIHR Manchester Biomedical Research Centre, Manchester, UK.ORCID 0000-0003-2733-6666
Hannah Jane DurringtonNIHR Manchester Biomedical Research Centre, Manchester, UK hannah.durrington@manchester.ac.uk.ORCID 0000-0002-9990-9446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma demonstrates a robust daily rhythm, with airflow obstruction and airway inflammation peaking overnight. Aligning the timing of drug administration with rhythms in disease (chronotherapy) may improve therapeutic efficacy. We aimed to evaluate the impact of dosage timing for inhaled corticosteroids in asthma.

methodsThis is a randomised three-way crossover trial. Participants with mild to moderate atopic asthma were randomised to beclometasone dipropionate: (1) 400 µg once daily between 08:00 and 09:00 (OD

resultsOf 25 participants, 21 completed all regimens. OD

conclusionOD

Indexed as

Adrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaBeclomethasoneGlucocorticoidsAdministration, InhalationAdultCross-Over StudiesDose-Response Relationship, DrugDrug Administration ScheduleFemaleForced Expiratory VolumeHumansMaleMiddle AgedSpirometryAdrenal Cortex HormonesAnti-Asthmatic AgentsBeclomethasoneGlucocorticoidsAsthmaInhaler devicesLung Physiology

Identifiers

PMID40234005
PMCPMC12322457

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.