Evidence map›Paper›PMID 40233938›Full record

ArticleJournal of applied microbiology2025

Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential.

Sergios-Orestis Kolokotronis, Chandrima Bhattacharya, Rupobrata Panja, Ian Quate, Matthew Seibert, Ellen Jorgensen, Christopher E Mason, Elizabeth M Hénaff

Abstract read
In one paragraph

Article in Journal of applied microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sergios-Orestis KolokotronisDepartments of Epidemiology and Biostatistics, Medicine, and Cell Biology, SUNY Downstate Health Sciences University, 450 Clarkson Ave, Brooklyn, NY, United States.ORCID 0000-0003-3309-8465
Chandrima BhattacharyaDepartment of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue 0021, United States.
Rupobrata PanjaCenter for Computational and Integrative Biology, Rutgers University, 201 S Broadway Camden, NJ 08103, United States.
Ian QuateFruit Studio, 352 Depot Street, Suite 250, Asheville, NC 28801, United States.
Matthew SeibertSchool of Architecture, University of Virginia, Campbell Hall, PO Box 400122, Charlottesville, VA 22904, United States.
Ellen JorgensenBiotech without Borders, 43-01 21st St Suite 319, Long Island City, NY 11101, United States.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue 0021, United States.
Elizabeth M HénaffNYU Tandon School of Engineering, Integrated Design and Media, Center for Urban Science and Progress, Chemical and Biomolecular Engineering, 370 Jay Street, Brooklyn, NY 11201, United States.ORCID 0000-0001-7906-9681

Funding

Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycleR01AI125416 · NIAID · DUKE UNIVERSITY · PI Stacy Michelle Horner · 2016 to 2026
$5.5M
Multiethnic genomic epigenomic and transcriptomic fine-mapping and functional validation analysis of schizophrenia and bipolar disorder risk lociR01MH125246 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2021 to 2025
$5.0M
NASA 80NSSC24K0728National Science Foundation 1758800NIH HHS R01AI125416NIMH NIH HHS R01 MH125246
6 · The paper itself

Abstract

aimsWe investigate the bioremediation potential of the microbiome of the Gowanus Canal, a contaminated waterway in Brooklyn, NY, USA, designated a Superfund site by the US Environmental Protection Agency due to high concentrations of contaminants, including polychlorinated biphenyls, petrochemicals, and heavy metals. METHODS AND

resultsWe present a metagenomic analysis of the Gowanus Canal sediment, consisting of a longitudinal study of surface sediment and a depth-based study of sediment core samples. We demonstrate that the resident microbiome includes 455 species, including extremophiles across a range of saltwater and freshwater species, which collectively encode 64 metabolic pathways related to organic contaminant degradation and 1171 genes related to heavy metal utilization and detoxification. Furthermore, our genetic screening reveals an environmental reservoir of antimicrobial resistance markers falling within 8 different classes of resistance, as well as de-novo characterization of 2319 biosynthetic gene clusters and diverse groups of secondary metabolites with biomining potential.

conclusionThe microbiome of the Gowanus Canal is a biotechnological resource of novel metabolic functions that could aid in efforts for bioremediation, AMR reservoir mapping, and heavy metal mitigation.

Indexed as

BacteriaDrug Resistance, BacterialGeologic SedimentsMicrobiotaBiodegradation, EnvironmentalMetagenomeMetagenomicsMetals, HeavyPolychlorinated BiphenylsWater Pollutants, ChemicalMetals, HeavyPolychlorinated BiphenylsWater Pollutants, Chemicalantimicrobial resistancebiominingbioremediationenvironmental contaminationEPA Superfundmetagenomics

Identifiers

PMID40233938
PMCPMC11999716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.