Evidence map›Paper›PMID 40233764›Full record

ArticleEmerging infectious diseases2025

Safety and Immunogenicity of Poultry Vaccine for Protecting Critically Endangered Avian Species against Highly Pathogenic Avian Influenza Virus, United States.

Todd E Katzner, Ashleigh V Blackford, Mary Donahue, Samantha E J Gibbs, Julianna Lenoch, Michael Martin, Tonie E Rocke, J Jeffrey Root, Darrel Styles, Sunny Cooper and 12 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Todd E Katzner
Ashleigh V Blackford
Mary Donahue
Samantha E J Gibbs
Julianna Lenoch
Michael Martin
Tonie E Rocke
J Jeffrey Root
Darrel Styles
Sunny Cooper
Kristin Dean
Zachary Dvornicky-Raymond
Dominique Keller
Carlos Sanchez
Brett Dunlap
Thomas Grier
Michael P Jones
Gregory Nitzel
Erin Patrick
Maureen Purcell
Aaron J Specht
David L Suarez

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2023, an outbreak of highly pathogenic avian influenza occurred among critically endangered California condors (Gymnogyps californianus), and >21 died. We evaluated safety, immunogenicity, vaccination strategies, and correlates of antibody response of an influenza vaccine for poultry in black vultures (Coragyps atratus) and then California condors. We noted differences in antibody titers between vaccinated and unvaccinated birds (vultures p<0.004; condors p-<0.02) but no adverse effects of vaccination. All vaccinated vultures and 80% of vaccinated condors showed maximum measured antibody response within the published range associated with survival of vaccinated and virally challenged chickens. We noted weak evidence of higher antibody responses for birds given two 0.5-mL vaccines versus those given one 1-mL vaccine but no correlation between antibody titers and sex for either species or between antibody titers and bone lead concentrations in vultures. Our results prompted initiation of a vaccination program for condors that could reduce spread of this disease among highly threatened species.

Indexed as

Endangered SpeciesImmunogenicity, VaccineInfluenza A virusInfluenza in BirdsInfluenza VaccinesAnimalsAntibodies, ViralFemaleMalePoultryUnited StatesVaccinationAntibodies, ViralInfluenza VaccinesBlack vultureCalifornia condorCoragyps atratusGymnogyps californianusH5N1highly pathogenic avian influenza virusinactivated vaccineInfluenzarespiratory infectionsUnited Statesviruseszoonoses

Identifiers

PMID40233764
PMCPMC12123928

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.