ArticleNeuron2025
Primate thalamic nuclei select abstract rules and shape prefrontal dynamics.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.Neuron · 2026Article
- Disrupted thalamic functional hierarchy on resting-state fMRI in idiopathic generalized epilepsy.European radiology experimental · 2026Article
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- Thalamocortical orchestration of human theory of mind.bioRxiv : the preprint server for biology · 2026Article
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior.Nature communications · 2026Article
- A multi-region flexible neural interface for behavioral state decoding in freely moving mice.Microsystems & nanoengineering · 2026Article
- A. J. Major et al. reply.Nature neuroscience · 2026Article
- Protocol for testing global neuronal workspace and integrated information theories of consciousness in non-human primates and mice.PloS one · 2026Article
- Review
- Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Comprehensive mapping of the thalamic commissures in the rodent brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
- A ubiquitous spectrolaminar motif across independent studies, including Mackey et al.'s own data.bioRxiv : the preprint server for biology · 2025Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
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13 authors.
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Abstract
Flexible behavior depends on abstract rules to generalize beyond specific instances and outcome monitoring to adjust actions. Cortical circuits are posited to read out rules from high-dimensional representations of task-relevant variables in prefrontal cortex (PFC). We instead hypothesized that converging inputs from PFC, directly or via basal ganglia (BGs), enable the thalamus to select rules. We measured activity across PFC and connected thalamic nuclei of monkeys applying rules. Abstract rule information first appeared in ventroanterior thalamus (VA)-the main thalamic hub between BG and PFC. Mediodorsal thalamus (MD) also represented rule information before PFC, persisting to help maintain activation of relevant PFC cell ensembles. MD, a major recipient of midbrain dopamine input, was the first to represent information about behavioral outcomes. A PFC-BG-thalamus model reproduced key findings, and thalamic-lesion modeling disrupted PFC rule representations. This suggests that the thalamus selects high-level cognitive information from PFC and monitors behavioral outcomes of these selections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.