Evidence map›Paper›PMID 40233320›Full record

ArticleBlood2025

DNMT3A mutations are unlikely to affect interferon alfa treatment outcomes in patients with polycythemia vera.

Ghaith Abu-Zeinah, Katie Erdos, Neville Lee, Yara Ganom, Christoph Klade, Kurt Krejcy, Heinz Gisslinger, Richard T Silver, Joseph M Scandura

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ghaith Abu-ZeinahDivision of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-1881-3670
Katie ErdosDivision of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY.
Neville LeeDivision of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY.
Yara GanomDivision of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY.
Christoph KladeAOP Orphan Pharmaceuticals GmbH, Vienna, Austria.
Kurt KrejcyAOP Orphan Pharmaceuticals GmbH, Vienna, Austria.
Heinz GisslingerDivision of Hematology and Blood Coagulation, Department of Internal Medicine, Medical University of Vienna, Vienna, Austria.
Richard T SilverDivision of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY.
Joseph M ScanduraDivision of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY.ORCID 0000-0002-9525-143X

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Controlling the Niche to Control Clonal HematopoiesisR01HL175556 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joseph Michael Scandura · 2025 to 2026
$1.6M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NHLBI NIH HHS R01 HL175556
6 · The paper itself

Abstract

abstractDNMT3A mutations in patients with polycythemia vera were heterogeneous and not enriched in interferon alfa-treated patients. DNMT3A mutations had no detectable impact on the hematologic response, molecular response, or survival outcomes.

Indexed as

DNA (Cytosine-5-)-MethyltransferasesInterferon-alphaMutationPolycythemia VeraAdultAgedDNA Methyltransferase 3AFemaleHumansMaleMiddle AgedTreatment OutcomeDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanInterferon-alpha

Identifiers

PMID40233320
PMCPMC12290514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.