Evidence map›Paper›PMID 40233319›Full record

ArticleBlood2025

Maternal Tmprss6 is required for hepcidin suppression and fetal health.

Katherine L Fielding, Cavan Bennett, Anne Pettikiriarachchi, Naomi Jones, Rebecca Harding, Alistair R D McLean, Louise Randall, Ute Schaeper, Alberto Martinez, Ricardo Ataíde and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Katherine L FieldingInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Cavan BennettInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0002-9796-9381
Anne PettikiriarachchiInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Naomi JonesInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Rebecca HardingInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0003-4267-716X
Alistair R D McLeanInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0003-3449-7142
Louise RandallInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Ute SchaeperDrug Discovery Department, Silence Therapeutics GmbH, Berlin, Germany.ORCID 0000-0003-2556-8391
Alberto MartinezDepartment of Clinical Science, Silence Therapeutics PLC, Berlin, Germany.
Ricardo AtaídeInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0002-1014-0432
Sant-Rayn PasrichaInfection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0002-5502-0434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractThe antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.

Indexed as

FetusHepcidinsMembrane ProteinsSerine EndopeptidasesAnimalsFemaleHumansMiceMice, KnockoutPregnancyHepcidinsmatriptase 2Membrane ProteinsSerine Endopeptidases

Identifiers

PMID40233319
PMCPMC12824694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.