Evidence map›Paper›PMID 40233289›Full record

ArticleThe Pediatric infectious disease journal2025

Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.

Gabriela Patten, Karen Malateste, Carolyn Bolton Moore, Nosisa Sipambo, Limpho Mokone, Nanina Anderegg, Kara Wools-Kaloustian, Denna Michael, Francesca Odhiambo, Charles Kasozi and 16 more

Abstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Gabriela PattenFrom the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-2511-1367
Karen MalatesteUniversity of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.
Carolyn Bolton MooreCentre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.
Nosisa SipamboDepartment of Paediatrics and Child Health, Harriet Shezi Children's Clinic, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Johannesburg, South Africa.
Limpho MokoneSolidarMed, Maseru, Lesotho.
Nanina AndereggInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Kara Wools-KaloustianDepartment of Medicine, Indiana University School of Medicine; Indianapolis, Indiana.
Denna MichaelTanzanian National Institute of Medical Research, Mwanza, Tanzania.
Francesca OdhiamboCentre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Charles KasoziMasaka Regional Referral Hospital, Masaka City, Uganda.
Sophie DesmondeCentre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), French National Institute for Health and Medical Research (Inserm), University of Toulouse 3, UMR 1295, Toulouse, France.
Madeleine Amorissani-FolquetPediatric Department, Cocody University Hospital, Abidjan, Cote d'Ivoire.
Valériane LeroyCentre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), French National Institute for Health and Medical Research (Inserm), University of Toulouse 3, UMR 1295, Toulouse, France.
Dewi Kumara WatiDepartment of Pediatrics, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Udayana University, Bali, Indonesia.
Revathy NallusamyDepartment of Pediatrics, Penang Hospital, Penang, Malaysia.
Aarti KinikarDepartment of Pediatrics, BJ Government Medical College and Sassoon General Hospital, Pune, India.
Du Tuan QuyChildren's Hospital 1, Ho Chi Minh City, Vietnam.
Marcel YotebiengDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Peter Vanes EbasoneClinical Research Education, Networking and Consultancy (CRENC), Yaoundé, Cameroon.
Patricia LeloKalembe Lembe Pediatric Hospital, Kinshasa, Democratic Republic of the Congo.
Jorge PintoSchool of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Vanessa RouzierCentres GHESKIO, Port-au-Prince, Haiti.
Daisy Maria MachadoDepartment of Pediatrics, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.
Nel Jason HawDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Nathan FordFrom the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
International epidemiology Databases to Evaluate AIDS collaboration

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Leslie Anne Enane, AGGREY SEMWENDERO SEMEERE · 2006 to 2026
$57.7M
Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
WADA (West Africa Database on Antiretroviral Therapy) CollaborationU01AI069919 · NIAID · UNIVERSITY OF BORDEAUX II · PI Didier Koumavi Ekouevi, Antoine Jaquet · 2006 to 2026
$29.9M
Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research NetworksR24AI124872 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Stephany Norah Duda · 2016 to 2026
$12.5M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Vasiliki Michopoulos · 2018 to 2026
$12.2M
NIAID NIH HHS R24 AI124872NIAID NIH HHS U01 AI069907NIAID NIH HHS U01 AI069911NIAID NIH HHS U01 AI069919NIAID NIH HHS U01 AI069923NIAID NIH HHS U01 AI069924NIAID NIH HHS U01 AI096299NIA NIH HHS U54 AG062334World Health Organization 001
6 · The paper itself

Abstract

Eligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.

Indexed as

Anti-HIV AgentsHIV InfectionsAdolescentCD4 Lymphocyte CountChildChild, PreschoolCohort StudiesFemaleGlobal HealthHumansInfantMaleAnti-HIV Agentsadvanced HIV diseaseantiretroviral therapyCD4 cell countpediatric HIVsevere immune suppression

Identifiers

PMID40233289
PMCPMC12314732

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.