ArticleEnvironmental health perspectives2025
Outdoor Exposure to Artificial Light at Night and Breast Cancer Risk: A Case-Control Study Nested in the E3N-Generations Cohort.
Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Reducing artificial light at night exposure in the urban environment could decrease light pollution-related hypertension in children.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
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7 authors.
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Abstract
backgroundExposure to light at night (LAN), particularly blue light, is suspected to disrupt circadian rhythm, inhibit melatonin production, and eventually increase the risk of breast cancer.
objectivesWe assessed the association between exposure to outdoor LAN and breast cancer risk in the E3N-Generations cohort, a large population-based cohort study of French women followed-up from 1990 to 2011.
methodsWe conducted a nested case-control study in the cohort, including 5,222 incident breast cancer cases and 5,222 matched controls. Outdoor LAN exposure at residential addresses was assessed using radiance-calibrated satellite images from the Defense Meteorological Satellite Program (DMSP). Logistic regression models were used to obtain odds ratios (OR) and 95% confidence intervals (CIs), adjusting for socio-demographic, reproductive, hormonal, and lifestyle-related factors, as well as exposure to air pollutants (
resultsBefore adjustment for environmental covariates, the ORs associated for LAN exposure increased monotonically from the first to the fourth quartile. This increasing trend was less pronounced after adjustment for air pollutants (
conclusionThe weak positive associations observed in this study that persist after adjustment for environmental covariates, support the hypothesis that outdoor LAN may increase breast cancer risk. Our results, suggesting that urban greenness could mitigate the role of LAN exposure in breast cancer risk, should be investigated further. Future studies on cancer risk in relation to outdoor LAN should assess exposure to indoor sources, including electronic devices, and characterize the light spectrum, particularly the blue light. https://doi.org/10.1289/EHP15105.
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