Evidence map›Paper›PMID 40233022›Full record

ArticlePloS one2025

Extra virgin olive oil mitigates lung injury in necrotizing enterocolitis: Effects on TGFβ1, Caspase-3, and MDA in a neonatal rat model.

Mustafa Tuşat, Recep Eröz, Ferhan Bölükbaş, Erkan Özkan, Mehmet Semih Demirtaş, Hüseyin Erdal, Osman Okan Özocak

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In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Exosomal peptides and proteins in wound healing and skin regeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mustafa TuşatAksaray University Medical Faculty, Department of Pediatric Surgery, Aksaray University, Aksaray, Turkey.ORCID https://orcid.org/0000-0003-2327-4250
Recep ErözAksaray University Medical Faculty, Department of Medical Genetics, Aksaray University, Aksaray, Turkey.
Ferhan BölükbaşAksaray University Veterinary Faculty, Department of Histology and Embryology, Aksaray University, Aksaray, Turkey.
Erkan ÖzkanAksaray University Veterinary Faculty, Department of Parasitology, Aksaray University, Aksaray, Turkey.ORCID https://orcid.org/0000-0002-5251-2302
Mehmet Semih DemirtaşAksaray University Medical Faculty, Department of Pediatrics, Aksaray University, Aksaray, Turkey.ORCID https://orcid.org/0000-0003-2965-1811
Hüseyin ErdalAksaray University Veterinary Faculty, Department of Histology and Embryology, Aksaray University, Aksaray, Turkey.
Osman Okan ÖzocakErciyes University Medical Faculty, Department of Cardiovascular Surgery, Erciyes University, Kayseri, Turkey.ORCID https://orcid.org/0000-0002-2339-0131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NE), which is common in premature babies, has been associated with lung damage. Our aim is to explore the effect of enterally administered extra virgin olive oil (EO) with rich polyphenol content on clinical parameters, histopathological score, Transforming growt factor beta-1 (TGFβ1), Caspase 3 and Malondialdehyde (MDA) levels in NE-related lung injury of neonatal rats.

methodsThree groups (control, NE, NE+EO) were created, with 8 neonatal rats in each group. NE was induced by hypoxia-hyperoxia-hypothermia and formula feeding. EO was given to the treatment group by orogastric probe for 3 days. Intestinal and lung tissue were excised for analysis.

resultsTGFβ1 expression levels, TGFβ1 and MDA concentration levels were higher in the NE compared to NE +  EO and control groups (p < 0.001), and their levels decreased after EO treatment compared to the NE group (p < 0.001). It was determined that EO treatment significantly reduced the histopathological damage and the caspase-3 (CASP3) expression level in the lung (p < 0.001).

conclusionOur findings emphasize that TGFß1 has an crucial function in NE-related lung injury and that EO has therapeutic potential in NE-related lung injury.

Indexed as

Caspase 3Enterocolitis, NecrotizingLung InjuryMalondialdehydeOlive OilTransforming Growth Factor beta1AnimalsAnimals, NewbornDisease Models, AnimalLungMaleRatsCasp3 protein, ratCaspase 3MalondialdehydeOlive OilTgfb1 protein, ratTransforming Growth Factor beta1

Identifiers

PMID40233022
PMCPMC11999148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.