ArticleeLife2025
The extra-islet pancreas supports autoimmunity in human type 1 diabetes.
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Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata.Nature metabolism · 2026Article
- Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods.Nature communications · 2026Article
- Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices.Science advances · 2026Article
- Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes.Cell reports · 2026Article
- Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.Nature communications · 2026Article
- Stress-driven remodeling of antigen presentation and chemokine signaling in pancreatic β-cells: implications for type 1 diabetes.Frontiers in immunology · 2026Review
- Neoepitopes at the crossroads of immunometabolism: metabolic remodeling of antigen presentation in type 1 diabetes.Frontiers in immunology · 2026Review
- SPACEc: a streamlined, interactive Python workflow for multiplexed image processing and analysis.Nature communications · 2025Article
- Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes.bioRxiv : the preprint server for biology · 2025Article
- Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices.bioRxiv : the preprint server for biology · 2025Article
- Association of Early Pregnancy Inflammatory Indices with Preterm Birth and Perinatal Outcomes in Pregnancies with Pregestational Diabetes.Journal of clinical medicine · 2025Article
- Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas.Journal for immunotherapy of cancer · 2025Article
- Tissue Resident and Infiltrating Immune Cells: Their Influence on the Demise of Beta Cells in Type 1 Diabetes.Biomolecules · 2025Review
- Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.bioRxiv : the preprint server for biology · 2025Article
- The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis.Frontiers in endocrinology · 2025Review
- Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity.Frontiers in immunology · 2025Review
- Insulitis in human type 1 diabetes: lessons from an enigmatic lesion.European journal of endocrinology · 2024Article
- Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development.Frontiers in endocrinology · 2023Article
Corrections and comments
- Update of
Authors and funding
15 authors.
Graham L BarlowDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.ORCID https://orcid.org/0000-0001-9335-5414
Christian M SchürchDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Salil S BhateDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Darci J PhillipsDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Arabella YoungDiabetes Center, University of California, San Francisco, San Francisco, United States.
Shen DongDiabetes Center, University of California, San Francisco, San Francisco, United States.
Hunter A MartinezDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Gernot KaberDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Nadine NagyDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Sasvath RamachandranDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Janet MengDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Eva KorposInstitute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Interfaculty Center, University of Muenster, Muenster, Germany.
Jeffrey A BluestoneDiabetes Center, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0001-8793-7848
Garry P NolanDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Paul L BollykyDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, United States.ORCID https://orcid.org/0000-0003-2499-9448
Funding
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MStanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5MThe Cellular Geography of Therapeutic Resistance in CancerU2CCA233195 · NCI · DANA-FARBER CANCER INST · PI JOHNSON, BRUCE E. · 2018 to 2023
$13.7MSpatial-Genomic Integrative Multi-Species Analysis of Lymph Node MetastasisU54CA209971 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P, PLEVRITIS, SYLVIA KATINA · 2016 to 2021
$11.0MThe Lung PCA: A Multi-Dimensional Atlas of Pulmonary PremalignancyU2CCA233238 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DUBINETT, STEVEN M., SPIRA, AVRUM E · 2018 to 2021
$7.0MTissue Cytokine Sequestration and Immune Regulation in AutoimmunityU01AI101984 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$5.0MDeveloping strategies to inhibit cancer immunotherapy-induced immune-related adverse events without impeding anti-tumor immunityK99CA246061 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOUNG, ARABELLA · 2020 to 2021
$251kBreakthrough T1D nPOD: 5-SRA-2018-557-Q-RBreakthrough T1D nPOD RRID:SCR_014641Helmsley Charitable Trust #2018PG-T1D053,G-2108-04793NCI NIH HHS K99 CA246061NCI NIH HHS U2C CA233195NCI NIH HHS U2C CA233238NCI NIH HHS U54 CA209971NIAID NIH HHS T32 AI007290NIAID NIH HHS U01 AI101984NIDDK NIH HHS P30 DK116074NIH HHS 1U2CCA233238-01NIH HHS 5U01AI101984-09NIH HHS 5U2CCA233195-02NIH HHS 5U54CA209971-05NIH HHS K99CA246061Swiss National Science Foundation P300PB_171189Swiss National Science Foundation P400PM_183915
Abstract
In autoimmune type 1 diabetes (T1D), immune cells infiltrate and destroy the islets of Langerhans - islands of endocrine tissue dispersed throughout the pancreas. However, the contribution of cellular programs outside islets to insulitis is unclear. Here, using CO-Detection by indEXing (CODEX) tissue imaging and cadaveric pancreas samples, we simultaneously examine islet and extra-islet inflammation in human T1D. We identify four sub-states of inflamed islets characterized by the activation profiles of CD8
Indexed as
AutoimmunityDiabetes Mellitus, Type 1Islets of LangerhansPancreasAdultCD8-Positive T-LymphocytesFemaleHumansMaleautoimmunityhumanimmunologyinflammationtype 1 diabetes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.