ArticleeLife2025
An anatomical and physiological basis for flexible coincidence detection in the auditory system.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.Nature communications · 2026Article
- Regulatory Networks Driving the Specification, Differentiation, and Diversification of Neurons in the Mouse Inner Ear.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.bioRxiv : the preprint server for biology · 2025Article
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.Research square · 2025Article
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons.Cell reports · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- A Computational Model of Auditory Chirp-Velocity Sensitivity and Amplitude-Modulation Tuning in Inferior Colliculus Neurons.Research square · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
Animals navigate the auditory world by recognizing complex sounds, from the rustle of a predator to the call of a potential mate. This ability depends in part on the octopus cells of the auditory brainstem, which respond to multiple frequencies that change over time, as occurs in natural stimuli. Unlike the average neuron, which integrates inputs over time on the order of tens of milliseconds, octopus cells must detect momentary coincidence of excitatory inputs from the cochlea during an ongoing sound on both the millisecond and submillisecond time scale. Here, we show that octopus cells receive inhibitory inputs on their dendrites that enhance opportunities for coincidence detection in the cell body, thereby allowing for responses both to rapid onsets at the beginning of a sound and to frequency modulations during the sound. This mechanism is crucial for the fundamental process of integrating the synchronized frequencies of natural auditory signals over time.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.