Evidence map›Paper›PMID 40232944›Full record

ArticleeLife2025

Serial 'deep-sampling' PCR of fragmented DNA reveals the wide range of

Brooke E White, Carolyn L Hodo, Sarah Hamer, Ashley B Saunders, Susana A Laucella, Daniel B Hall, Rick L Tarleton

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Vaccines against chronicExpert review of vaccines · 2026
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Brooke E WhiteCenter for Tropical and Emerging Global Disease, Athens, United States.
Carolyn L HodoMichale E. Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, United States.
Sarah HamerDepartment of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, United States.
Ashley B SaundersDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, United States.
Susana A LaucellaResearch Department, Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben", Buenos Aires, Argentina. Chagas Disease Unit, Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina.
Daniel B HallDepartment of Statistics, University of Georgia, Athens, United States.
Rick L TarletonCenter for Tropical and Emerging Global Disease, Athens, United States.ORCID https://orcid.org/0000-0002-9589-5243

Funding

UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3M
Optimizing blood PCR as test of cure in Chagas diseaseR03AI166504 · NIAID · UNIVERSITY OF GEORGIA · PI TARLETON, RICK L · 2022 to 2023
$151k
NCATS NIH HHS UL1 TR003163NIAID NIH HHS R03 AI166504NIH HHS 1UL1TR003163NIH HHS R03 AI166504
6 · The paper itself

Abstract

Infection with the protozoan parasite

Indexed as

Chagas DiseaseDNA FragmentationDNA, ProtozoanParasite LoadPolymerase Chain ReactionTrypanosoma cruziAnimalsDogsHumansMacacaDNA, ProtozoanChagas diseaseinfectious diseasemicrobiologyPCRtest of curetrypanosoma cruziTrypanosoma cruzi

Identifiers

PMID40232944
PMCPMC11999692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.