Evidence map›Paper›PMID 40232893›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Targeting MLL1/WDR5-Mediated Epigenetic Regulation Mitigates Peritoneal Fibrosis by Reducing p16

Daisuke Hara, Kensuke Sasaki, Shigehiro Doi, Takeshi Ike, Kazuya Maeda, Maria Yoshida, Akira Takahashi, Yosuke Osaki, Naoki Ishiuchi, Yujiro Maeoka and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Magnesium Attenuates Renal Senescence and Fibrosis With Reduced DNA Damage Response and H3K4me3 Enrichment at the p16FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daisuke HaraDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Kensuke SasakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.ORCID https://orcid.org/0000-0001-5899-0885
Shigehiro DoiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Takeshi IkeDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Kazuya MaedaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Maria YoshidaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Akira TakahashiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Yosuke OsakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Naoki IshiuchiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Yujiro MaeokaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Toshiki DoiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Takuto ChibaDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ayumu NakashimaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Takao MasakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.

Funding

The role of maladaptive VEGFR2 signaling in renal stroma for chronic kidney diseaseK01DK133635 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Takuto Greco Chiba · 2023 to 2026
$481k
HHS|NIH|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K01-DK133635Japanese Association of Dialysis Physicians (JAPD)MEXT|Japan Society for the Promotion of Science (JSPS) 20K17284NIDDK NIH HHS K01 DK133635Ryokufukai Foundation
6 · The paper itself

Abstract

Peritoneal fibrosis poses a significant challenge to the long-term efficacy of peritoneal dialysis (PD), with emerging evidence highlighting the role of cellular senescence in its pathogenesis. p16

Indexed as

Cyclin-Dependent Kinase Inhibitor p16Epigenesis, GeneticHistone-Lysine N-MethyltransferaseIntracellular Signaling Peptides and ProteinsMyeloid-Lymphoid Leukemia ProteinPeritoneal FibrosisAnimalsCellular SenescenceFemaleHistonesHumansMaleMiceMice, Inbred C57BLPyruvaldehydeCDKN2A protein, humanCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Histone-Lysine N-MethyltransferaseHistonesIntracellular Signaling Peptides and ProteinsKMT2A protein, humanKmt2a protein, mouseMyeloid-Lymphoid Leukemia ProteinPyruvaldehydeWDR5 protein, humanWdr5 protein, mouseepigeneticsMLL1/WDR5peritoneal dialysisperitoneal fibrosisperitoneal inflammationsenescence

Identifiers

PMID40232893
PMCPMC12059782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.