Impact of Antidepressants on Male Fertility and Seminal Parameters: A Systematic Review.

Lorena Oliveira de Paula Dos Santos, Paula Rafaela Queiroz da Silva, Nicoly Caixêta Gonçalves, Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo

Abstract readSystematic Review

PubMed Publisher

In one paragraph

Synthesis in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lorena Oliveira de Paula Dos SantosDepartamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Paula Rafaela Queiroz da SilvaDepartamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Nicoly Caixêta GonçalvesDepartamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Hugo Felix PeriniDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Gláucia Eloisa Munhoz de Lion SiervoDepartamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil. glaucia.siervo@uftm.edu.br.ORCID 0000-0003-2084-4203

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00221-22

6 · The paper itself

Abstract

Depressive disorders affect a significant number of individuals worldwide, including men of reproductive age. The impact of antidepressant treatment on seminal and fertility parameters remains inconclusive, with limited clinical studies available on this topic. This systematic review aimed to compile the existing literature on the influence of various antidepressants on sperm and fertility-related parameters in men. In April 2023, a bibliographic search was conducted using the PubMed/Medline, Web of Science, and Scopus databases. Search terms included"fertility,""sperm,"and"semen,"combined with terms related to various antidepressants and their respective drugs. Clinical studies investigating fertility and/or semen parameters following antidepressant treatment in men were included. Studies outside the scope of this review were excluded. Data collected included details of the intervention and outcomes-such as the class of antidepressant, specific drug, dosage, duration of treatment, and age of subjects-along with data on sperm analysis and fertility-related parameters. This review included 5 articles focused on human studies. Selective serotonin reuptake inhibitors (SSRIs) are the most studied class of antidepressants. Findings on sperm-related impairment are conflicting. The available human studies are limited and often involve short-term treatment regimens, which may not accurately reflect the effects of long-term exposure. This work highlights the significant gap in reliable evidence regarding the effects of antidepressant drugs on seminal and fertility parameters in men of reproductive age.

Indexed as

Antidepressive AgentsFertilityInfertility, MaleSemenSpermatozoaHumansMaleSelective Serotonin Reuptake InhibitorsSemen AnalysisAntidepressive AgentsSelective Serotonin Reuptake InhibitorsDepressive disorderDrugMale fertilitySperm

Identifiers

PMID40232638

DOI10.1016/j.jad.2012.06.007

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.