ArticleJournal of neuro-oncology2025
Acute side effects of proton and photon radiotherapy for medulloblastoma: a retrospective national multicenter study.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model.Molecular oncology · 2026Article
- Transcriptional regulation of nucleotide metabolism in medulloblastoma subtypes and prognostic implications analyzed by RNA-Seq.Journal of cancer research and clinical oncology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA comparison of acute toxicity between photon and proton radiotherapy (RT) for children undergoing treatment for medulloblastoma.
methodsThis retrospective multi-institutional cohort study included 96 children < 18 years treated for medulloblastoma in Sweden during 2008-2020. Patients treated with protons (n = 37) and photons (n = 59) were compared regarding acute side effects and radiation dose to intracerebral organs at risk (OARs). Data was collected from a prospectively maintained national database and was supplemented from a retrospective review of medical records. Acute symptoms were graded according to CTCAE (Common Terminology Criteria for Adverse Events), maximum grade occurring during RT and within 2 months after RT. Hematological toxicity was evaluated according to maximum grade and percentual reduction during RT.
resultsNo significant differences in incidence or severity of acute symptoms were observed between proton-RT and photon-RT; grade ≥ 2 fatigue (5.4 vs. 10.2%), headache (2.7 vs. 3.4%), nausea (43.2 vs. 42.4%), dermatitis (5.4 vs. 15.3%), gastrointestinal toxicity (0 vs. 0%), weight loss (10.8 vs. 8.5%). Median percentual reduction (0% vs. -11,25%) in hemoglobin was significantly smaller during proton-RT (p < 0.001). No difference was observed for leucocytes, neutrophiles, or platelets. Absorbed mean dose to intracranial OARs was significantly lower with proton-RT.
conclusionThis is one of the largest studies comparing acute side effects of proton-RT and photon-RT including only paediatric medulloblastoma patients. Proton-RT was safe and well tolerated regarding acute side effects. Absorbed dose to intracranial OARs was significantly lower with proton-RT. Further investigations of long-term side effects and cognitive evaluation is needed to show that this will translate into true clinical value for patients.
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