Evidence map›Paper›PMID 40232595›Full record

ArticleVeterinary research communications2025

Evaluation of chemical elements as potential biomarkers in the treatment of goat mastitis.

Ugonna Henry Uzoka, Juliana Miwa Fujikura, Richard Costa Polveiro, Jéssica Lobo Albuquerque Caldeira, Maria Júlia Fernandes Netto, Luísa Maria de Souza Menezes, Cristiane do Carmo Cesário, Fabricio Luciani Valente, Maria Aparecida Scatamburlo Moreira

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Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ugonna Henry UzokaDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Juliana Miwa FujikuraDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Richard Costa PolveiroDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Jéssica Lobo Albuquerque CaldeiraDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Maria Júlia Fernandes NettoDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Luísa Maria de Souza MenezesDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Cristiane do Carmo CesárioNucleo de Microscopia e Microanalise, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Fabricio Luciani ValenteDepartment of Veterinary, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Maria Aparecida Scatamburlo MoreiraDepartment of Veterinary, Laboratory of Bacterial Diseases, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil. masm@ufv.br.ORCID http://orcid.org/0000-0002-6902-2502

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mastitis significantly impacts dairy goat herds, causing substantial economic losses. The escalating challenge of multidrug-resistant bacteria has prompted research into alternative therapeutic strategies, including milk microbiota transfer and phytochemical treatments. This study evaluates milk chemical elements as potential biomarkers during alternative treatments for Staphylococcus warneri-induced goat mastitis. Seven female Parda Alpina goats were studied, with six receiving sequential treatments: milk microbiota transplantation (MMT) from the seventh goat (donor), two days later, intra-mammary 7-epiclusianone administration followed. The right udder of the six goats received the treatments and different time points while the left udder served as the control. Milk samples (n = 120) were analyzed using X-ray Energy Dispersive Spectroscopy (XEDS) to monitor trace and macro elements. Milk elemental level variations were observed across both treatments. Notable changes included increased iron levels from MMT initiation, reduced copper and zinc levels during MMT, and decreased sodium levels following 7-epiclusianone treatment. These results suggest zinc, copper, iron, and sodium could serve as potential biomarkers for monitoring mastitis treatment effectiveness. Additional research with broader and more diverse sample populations would help validate these findings and explore the method's broader applicability.

Indexed as

Goat DiseasesMastitisMilkStaphylococcal InfectionsAnimalsBiomarkersCopperFemaleGoatsStaphylococcusBiomarkersCopperBioactive compoundMicrobiota transplantationMilk elementsStaphylococcus warneriX-ray energy dispersive spectroscopy

Identifiers

PMID40232595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.