ArticleMolecular biology reports2025
Characterization of phenotypic and genotypic traits of Klebsiella pneumoniae strains resistant to 3rd generation cephalosporins in hospital settings: A case study in Ho Chi Minh City, Vietnam.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Genotype-Phenotype Links Between Aminoglycoside-Modifying Enzymes and Aminoglycoside MICs in Aminoglycoside-ResistantMicroorganisms · 2026Article
- Mathematical modelling of synergistic triple-antibiotic therapy against carbapenem-resistantJournal of medical microbiology · 2025Article
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5 authors.
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Abstract
backgroundKlebsiella pneumoniae is a dangerous pathogen, responsible for a variety of infections and has been growing resistance to antibiotics, making it difficult to treat diseases caused by this bacterium. A better understanding of the phenotypic and genotypic characteristics of this bacterium is essential for developing more effective treatments. This study examines the prevalence of Klebsiella pneumoniae in patient samples from eight hospitals in Ho Chi Minh City, Vietnam, in 2023, focusing on its AmpC β-lactamase, ESBL, and carbapenemase genotypes. METHODS AND
resultsA total of 230 Klebsiella pneumoniae strains were isolated from clinical specimens, including sputum, pus, urine, bronchial lavage fluid, blood, and other fluids. The disk diffusion method detected the presence of these resistance enzymes, while multiplex real-time PCR identified the associated genes. Results showed that 78.7% of isolates produced AmpC β-lactamase, 21.3% produced ESBL, and 27.0% produced carbapenemase. ESBL-producing strains (90.9%) were more common than AmpC (67.4%) and carbapenemase (45.7%) strains. Additionally, 27.0% of isolates produced multiple resistance enzymes. The most prevalent AmpC gene was DHA (63.5%), while SHV (84.3%), TEM (55.2%), and CTX-M (70.0%) were the most common ESBL genes. OXA-48 (31.3%) was the dominant carbapenemase gene, followed by NDM1 (24.8%) and KPC (9.1%). On average, each strain carried 3.3 resistance genes.
conclusionsThis study reveals a high prevalence of antimicrobial resistance in Klebsiella pneumoniae isolates from patient samples in Ho Chi Minh City hospitals, notably to third-generation cephalosporins and carbapenems. These findings highlight the need for ongoing surveillance and improved treatment strategies.
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