Evidence map›Paper›PMID 40232574›Full record

ArticleDigestive diseases and sciences2025

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT).

Meike de Wit, Evelien Dekker, Manon Spaander, Monique van Leerdam, Veerle Coupe, Gerrit Meijer, Beatriz Carvalho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meike de WitDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Evelien DekkerDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Manon SpaanderDepartment of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
Monique van LeerdamDepartment of Gastroenterology and Hepatology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Veerle CoupeDepartment of Epidemiology and Data Science, Decision Modeling Center, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Gerrit MeijerDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beatriz CarvalhoDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. b.carvalho@nki.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerFecesMass ScreeningOccult BloodHumansSensitivity and SpecificityBiomarker developmentCRC screeningFecal immunochemical test (FIT)Multitarget fecal immunochemical test (mtFIT)

Identifiers

PMID40232574
PMCPMC12125136

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.